| 邹德勇1 耿红艳2 王秀梅1 赵怡雯1 张小丽1
翁泽兵1 刘兰兰1 赵海滨1 郭晓今1 刘向祎2△.血清胱抑素C 检测在ICU 急性肾损伤中的意义[J].,2012,12(7):1300-1302 |
| 血清胱抑素C 检测在ICU 急性肾损伤中的意义 |
| The Application of Cystatin C (Cys C) in Valuation Acute Kidney Injuryin ICU Patients |
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| DOI： |
| 中文关键词: 胱抑素C 急性肾损伤 |
| 英文关键词: Cys C AKI |
| 基金项目:北京市临床生化参考测量体系的建立及应用（2009-1045） |
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| 中文摘要: |
| 目的：测定ICU 的急性肾损伤（AKI）患者和ICU 非AKI 患者的血清胱抑素C (Cys C)、Cr 及β2-MG 的水平，研究Cys C 在
AKI 中的应用价值。方法：采用日立7600-120 全自动生化分析仪测定ICU AKI 患者31 例和ICU 非AKI 患者24 例的Cys C、Cr、
β2-MG，用受试者工作曲线（ROC）评价Cys C 的诊断价值，采用spss 16.0 统计软件包进行统计分析。结果：ICU 的AKI 患者的
血清Cys C 水平较ICU 非AKI 对照组升高，有统计学意义，[Cys C]-1 与eGFR 呈正相关，r=0.711，P<0.001;与AKI 分期无统计学
意义。ROC 曲线分析证实Cys C 在AKI 的诊断中敏感性和特异性最好。结论：血清Cys C 可以做为ICU 病人发生AKI 的诊断
指标，为AKI 的及时诊断、肾功能的评估提供了可靠的依据，有助于临床更好的把握治疗时机。 |
| 英文摘要: |
| Objective: To explore the application of Cystatin C (Cys C) in valuation acute kidney injury in ICU Patients. Methods:
In this study, 55 patients were collected and divided into two groups, including 31 cases with AKI and 24 cases without AKI as controls.
We measured the serum concentration of Cys C, β2-MG , and Cr by HITACHI 7600-120 Automatic biochemical analyzer. The eGFR
was estimated the with MDRD equation. Then compared Cys C、Cr、β2-MG between two groups and the correlations with each other.
The diagnostic value of Cys C were evaluated by ROC curve with SPSS 16.0 software. Results: In AKI group, The serum level of Cys C
were significantly higher than that in non-AKI group (P<0.05), it has no significant difference among three periods (P>0.05). [Cys C]-1
was also positively correlated with eGFR （r=0.711，P<0.001). The ROCAUR of Cys C is 0.930. Conclusions: Cys C is a very useful
diagnostic indicator in AKI, especially in the early diagnose AKI, it could provide a reliable assessment of renal function and grasp the
right opportunity to better treatment. |
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