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目的：研究阻塞性睡眠呼吸暂停综合征与高血压的临床关系及相关机制。方法：将258 例鼾症患者分为三组：单纯鼾症对照组（N 组）、单纯OSAHS 组(O 组) 、OSAHS 合并高血压组（O+H 组）。对三组患者进行临床基础资料收集，ESS 问卷调查及EP 评分，多导睡眠监测及血压测定。结果：三组鼾症患者之间年龄、性别、吸烟、饮酒差异无统计学意义（P＞0.05），OSAHS 组及 OSAHS+HT 组体重指数及颈围明显高于单纯鼾症组，差异有统计学意义（P＜0.05）；与单纯鼾症组比较，OSAHS 组及 OSAHS+HT 组的EP 评分、AHI、LaSO2 (%)、MSaO2、Ts90%差异明显有统计学意义（P＜0.05）；与对照组相比OSAHS 组及 OSAHS+HT 组睡眠前后收缩压和舒张压升高，差异有统计学意义（P＜0.05）。结论：阻塞性睡眠呼吸暂停综合征与高血压关系密切，慢性间歇缺氧是引起高血压的核心机制。

英文摘要:

Objective: To research the clinical relationship and mechanism between obstructive sleep apnea syndrome (OSAHS) and hypertension. Method: 258 patients were allocated to pure treating sleep apnea (N) and Pure OSAHS (O) and OSAHS and hypertension (O+H) according to patient's intention and condition. Three groups of patients with clinical foundation data collection, ESS questionnaire survey and EP score, polysomnography monitoring and blood pressure measurement. Results: The difference of which all three groups on age, sex, smoking, drinking was no significant difference (P<0.05). But compared with control group, OSAHS group and OSAHS + HT group, the difference of BMI and NC was statistically significant (P<0.05); The difference of which OSAHS group and OSAHS + HT group compared with the control group on AHI, Ts90, LsaO2, MsaO2 is statistically significant (P<0.05); The difference of which OSAHS group and OSAHS + HT group compared with control group on systolic and diastolic blood pressure before and after sleeping, is statistically significant (P<0.05). Conclusion: We concluded that OSAHS is associated with hypertension closely,chronic intermittent hypoxia is the cardinal mechanism which causing hypertension.

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