| 于志华李震王伟陈诗师王云锋崔岗△.Foxj1 在脑外伤后的表达变化[J].,2012,12(7):1244-1246 |
| Foxj1 在脑外伤后的表达变化 |
| The Expression of Foxj1 after Traumatic Brain Injury |
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| DOI： |
| 中文关键词: Foxj1 脑外伤 大鼠 |
| 英文关键词: Foxj1 Traumatic brain injury Rats |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨脑外伤后Foxj1 在脑组织中的表达变化及其意义。方法：建立大鼠脑外伤模型，利用Western blot 和免疫组织化学
方法检测脑外伤后Foxj1 在脑组织中表达的变化。结果：Western blot 显示大鼠脑外伤后，Foxj1 的表达逐步增高，伤后3 d 升至最
高点，之后逐渐降低；免疫组织化学的结果与Western blot 一致。结论：脑外伤后Foxj1 在脑组织中的表达增高，这种增高的表达参
与了脑外伤后脑组织的病理生理和生化变化。 |
| 英文摘要: |
| Objective: The goal of this study was to evaluate the expression of Foxj1 in the central nervous system after Traumatic
Brain Injury. Methods: The brain stab-injury models of rat were performed. Western blot and immunohistochemistry analysis were used
to investigate the expression of Foxj1 at various times after injury. Results: Foxj1 proteins around lesion site increased gradually and
reached its maximum at the 3d post-injury, after that, the expression level began to decline. Immunohistochemistry showed similar results
as Western blot. Conclusions: The increased expression of Foxj1 may be involved in the pathophysiological and biochemical progression
after Traumatic Brain Injury. |
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