| 张国桥易诚青△ 滕松松宋旺胜.早期激素性股骨头坏死模型的建立[J].,2012,12(7):1223-1224 |
| 早期激素性股骨头坏死模型的建立 |
| Construction of the Model of First-Stage Steroid-Induced Femoral HeadNecrosis in Rabbits |
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| DOI： |
| 中文关键词: 早期 激素性股骨头坏死 脂多糖 甲基强的松龙 |
| 英文关键词: Steroid-induced osteoecrosis of femoral head Lipopolysaccharide Methylprednisolone First-stage |
| 基金项目:国家自然科学基金项目（30700853） |
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| 中文摘要: |
| 目的：建立早期股骨头坏死模型，为研究其发病机制及合理治疗方法的提供可靠的模型基础。方法：用单一剂量脂多糖LPS
(10 μg/kg)联合三次甲强龙MPS(10 mg/kg)注射，每次间隔24h，诱导建立兔早期股骨头坏死模型，通过影像学及组织病理性学方
法评估模型建立情况。结果：4 周后，模型组死亡1 例，模型组16 例X 线检查未见异常表现，2 例X 线提示股骨头密度不均，未出
现股骨头塌陷，18 例HE 染色示骨细胞空骨陷窝增多，脂肪细胞体积变大，数量增多。结论：用脂多糖（LPS）联合甲强龙可成功诱
导建立兔早期股骨头坏死模型，模型成功率高、死亡率低。 |
| 英文摘要: |
| Objective: To construct the model of first-stage steroid-induced osteonecrosis in rabbits and prepare to seek for
pathogenesis and rational treatment of first-stage osteonecrosis of femoral head. Methods: We constructed the model with lipopolysaccharide
(signal-dose 10ug/kg) plus methylprodnisolone (10mg/kg,three times every 24h internals)．The osteonecrosis model was
evaluated by X-ray examination and hematoxylin and eosin stain. Results: In model group，two samples were featured with uneven
density of femoral head in X-ray photograph.There were 18 samples with increased numbers of empty bone lacunae and larger quantity of
fat cells compared with normal grop under light microscopy and histological. Conclsion: The animal model was induced by LPS plus
MPS, with a high success rate and low mortality. |
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