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目的：探讨非小细胞肺癌不同肺叶切除手术方法对术后长期生活质量（QOL）影响。方法：采用生活质量测定量表核心量表 (QLQ-C30)调查从2005 年4 月1 日至2006 年3 月31 日在我科治疗的80 例非小细胞肺癌患者，将其分为两组，A 组：肺叶切除（单叶/ 双叶切除）；B 组：全肺切除术。对其术前和术后3，6 和12 个月的QLQ-C30 得分与参考值进行比较。结果：①术前术后生活质量相比较。功能方面，术后情绪功能，体力功能显着下降；症状方面，术后呼吸困难，疼痛明显加重；术后第3 个月疲乏明显加重；术后第3，6 个月经济困难较术前明显加重；②两组术后生活质量相比较，功能方面，术后B 组体力功能、角色功能、情绪功能及总体状况显著的降低；症状方面，B 组较A 组，术后疲乏显著升高，第3-12 个月疼痛，第3，6 个月呼吸困难均显著升高。结论：术后生活质量与术前比较，全肺切除对患者生活质量影响明显。比较两种方法，全肺切除组较肺叶切除患者术后长期生活质量下降明显。

英文摘要:

Objective: To investigate the long-term quality of life (QOL) in the treatment of NSCLC lobectomy by two surgical methods, lobectomy (or bilobectomy) and pneumonectomy. Methods: The quality of life questionnaire, EORTC QLQ-C30 Chinese version, was used to assess the patient's quality of life. All the 80 patients from April 1, 2005 to March 31, 2006 in our department treated for NSCLC with lobectomy (or bilobectomy) and pneumonectomy were collected in this study. The QLQ-C30 scores of preoperative and postoperative 3, 6 and 12 months were compared each other. Results: First, comparing the preoperative and postoperative quality of life, we found that emotional function and physical function decreased significantly, dyspnea and pain were aggravated significantly, and fatigue significantly increased in postoperative 3 months. Financial difficulties increased significantly 3 and 6 months after surgery also. Second, physical function, role function, emotional function and overall condition decreased significantly. That fatigue postoperative, dyspnea 3, 6 months postoperative, and pain 3-12 months postoperative were increased significantly in the pneumonectomy group. Conclusion: By comparing the preoperative and postoperative quality of life, pneumonectomy had significant impact on patients' life quality. Pneumonectomy decreased the long-term quality of life significantly than the lobectomy.

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