| 欧阳晓春余小骊景少巍△ 王水华张萃萍.七叶皂苷钠对一氧化碳中毒迟发性脑病大鼠模型细胞凋亡
及调控凋亡基因表达的影响[J].,2012,12(5):865-867 |
| 七叶皂苷钠对一氧化碳中毒迟发性脑病大鼠模型细胞凋亡
及调控凋亡基因表达的影响 |
| Effects of Sodium Aescinate on Cell Apoptosis and Expression ofApoptotic-Related Genes in Delayed Encephalopathy Rat Modelof Carbon Monoxide Poisoning |
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| DOI： |
| 中文关键词: 七叶皂苷钠 一氧化碳中毒 细胞凋亡 切冬酶-3 实验大鼠 |
| 英文关键词: Sodium Aescinate Carbon nonoxide poisoning Apoptosis Caspase-3 Animals laboratory Rats |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨七叶皂苷钠对一氧化碳中毒迟发性脑病大鼠模型细胞凋亡及Caspase-3 表达的影响。方法：将30 只大鼠随机分
为正常对照组、一氧化碳中毒迟发性脑病大鼠模型对照组和七叶皂苷钠治疗组，原位末端标记法(TUNEL)检测细胞凋亡，免疫组
化法检测Caspase-3 的表达。结果：治疗组大鼠脑细胞凋亡率及Caspase-3 表达较迟发性脑病对照组显著降低(P<0.01)。结论：七叶
皂苷钠对一氧化碳中毒迟发性脑病的脑保护作用机制可能与干预脑细胞凋亡相关基因表达并减少神经细胞凋亡有关。 |
| 英文摘要: |
| Objective: To observe the effects of Sodium Aescinate on cell apoptosis and the expression of caspase-3 in delayed
encephalopathy rat model of carbon monoxide poisoning. Methods: Thirty rats were randomly divided into three groups, that is, normal
group, delayed encephalopathy rate model of carbon monoxide poisoning control group and Sodium Aescinate treatment group. The cell
apoptosis was detected by TUNEL stacning. The expression of caspase-3 was determined by immunohistochemical staining. Results: The
cell apoptosis rate and the positive cell number of caspase-3 were significantly lower (P<0.01) in Sodium Aescinate treatment group than
those in the delayed encephalopathy after carbon monoxide poisoning control group. Conclusion: The protective effect of Sodium
Aescinate on the cerebral tissue after carbon monoxide poisoning may be related with its intervening in the expression of
apoptosis-related gene and decreasing the degree of nerve cell apoptosis. |
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