| 杨仁江高冠群张卓伯王岩谷莹丽.BRCA-1 基因与神经干细胞[J].,2012,12(4):788-790 |
| BRCA-1 基因与神经干细胞 |
| BRCA-1 and Neural Stem Cells |
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| DOI： |
| 中文关键词: Brca-1 基因 神经干细胞 增殖 |
| 英文关键词: BRCA-1 Neural stem cells Proliferation |
| 基金项目:完全相同,甚至可能相反，提示对P38 通路的功能仍需进一步的研究,他可能是肿瘤治疗的新靶点.本文就P38 MAPK 信号传导通 |
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| 中文摘要: |
| 乳腺癌易感基因（Breast cancer susceptibility gene, Brca-1）是肿瘤抑制基因家族中的一员，它是乳腺癌特异性抑癌基因，1994
年Miki 等[1]采用定位克隆方法首次将Brca-1 分离出来。Brca-1 能防止细胞过快地或失去控制地生长和分化，在调节细胞进程、
DNA 损伤修复、细胞生长与凋亡及转录活化和抑制等多种生物学途径都发挥重要作用，Korhonen 等2003 年报道Brca-1 基因可
促进体外培养的大鼠来源的神经干细胞的增殖。 |
| 英文摘要: |
| Breast cancer susceptibility gene (BRCA-1), a member of tumor suppressor gene family, by which breast cancer can
be inhibited specificly, was dissociated by Miki et al.through positioning cloning at 1994. It can prevent the over-quick or uncontrolled
growth and differentiation. It plays important roles in many fields, Such as regulation of cells process, repareation after DNA damage,
growth and apoptosis of cells, activation and inhibitiation of transcription and so on. In 2003, it was reported by Korhonen et al. that the
proliferation of vitro cultured neural stem cells of rat can be promoted by BRCA-1. |
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