| 李京佳林相国许涛徐万海王晓民△.VEGF 家族及其在肿瘤生长中作用的研究[J].,2012,12(4):777-779 |
| VEGF 家族及其在肿瘤生长中作用的研究 |
| VEGF and the Role of VEGF in Tumor Growth |
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| DOI： |
| 中文关键词: VEGF 肿瘤 血管生成 |
| 英文关键词: VEGF Tumor Growth Angiogenesis |
| 基金项目:黑龙江省科技攻关计划（GC07C35105） |
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| 中文摘要: |
| 血管内皮生长因子( Vascular Endothelial Growth Factor, VEGF)家族是一类多功能的细胞因子, 在血管生成和淋巴管生成中
具有直接和间接的调控作用,可促进内皮细胞增殖、促进血管生成以及增加血管的通透性。VEGF/VEGFR 轴由多重配基和受体质
量叠加交错组成, 并且受体与配基结合具有专一性, 在不同的细胞中具有不同的细胞类型表达和功能.启动VEGF 信号通路, 触发
了一个网状的信号过程, 从而促进血管内皮细胞生长、转移和存活。进来研究发现，VEGF 的一个重要作用表现为可动员内皮祖细
胞从骨髓向远处转移从而形成新生血管，因而有必要设计和发展针对这一途径的抑制因子。随着研究的深入，VEGF 促进肿瘤血
管生成的作用和与人类癌症的发病机制的关系是确定的,因此, 抑制VEGF 途径被确认为是一种重要的有效的抗癌模式 |
| 英文摘要: |
| Vascular Endothelial Growth Factor ( VEGF) family is a multifunctional kind of cytokine,which has direct or indirect
effect in angiogenesis and lymphangion generation.It can promote proliferation of endothelial cells, angiogenesis and increase the
permeability of blood vessels. The VEGF/VEGF-receptor axis is composed of multiple ligands and receptors with overlapping and
distinct ligand-receptor binding specificities, cell-type expression, and function.Activation of the VEGF signaling pathway triggers a
network of signaling processes that promote endothelial cell growth, migration, and survival from pre-existing vasculature. A recently
research show an important role of VEGF has emerged in mobilization of endothelial progenitor cells from the bone marrow to distant
site neovascularization. So, it is necessary to design and develop the inhibitory factors against the target pathway.With the research going
on,the role of VEGF promoting angiogenesis in tumor is related to the mechanism of cancer in human, and inhibiting the pathway of
VEGF is seemed an important effective way to resist cancer. |
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