| 李秀平尹卫东△.Visfatin 与2 型糖尿病研究新进展[J].,2012,12(4):765-767 |
| Visfatin 与2 型糖尿病研究新进展 |
| New Progress of Research on Visfatin and Type-2 Diabetes Mellitus |
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| DOI： |
| 中文关键词: Visfatin 内脏脂肪 2 型糖尿病 |
| 英文关键词: Visfatin Visceral adipocyte Type 2 Diabetes mellitus |
| 基金项目:国家重点基础研究发展计划资助项目："973" 计划资助项目(2010CB530406) |
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| 中文摘要: |
| Visfatin 是Fukuhara 等发现的一种蛋白质细胞因子,由内脏脂肪细胞分泌，受多种因素调节，有烟酰胺磷酸核糖转移酶活性，
类胰岛素作用，促炎作用等多种生物学作用。2 型糖尿病是一种内分泌代谢性疾病,由多基因遗传因素、环境因素综合作用引起,
visfatin 与其有密切的关系。Visfatin 对于寻找糖尿病新的药物靶点,开发新的疾病生物标志物有非常重要临床意义。 |
| 英文摘要: |
| As an novel adipocytokines recently discovered by Fukuhara et cetera, Visfatin is secreted from visceral adipocyte,
and regulated by various factors such as hormones, drugs, glucose, free fatty acids, lipopolysaccharide, Interleukin-1β, tumor necrosis
factor-α, growth hormone and so on. It also has a lot of effects such as insulin mimetic effects, nicotinamide phosphoribosyl transferase
activity. It is also involved in the inflammatory response, and has immunifaction, autocrine and paracrine functions. It regulates lipid
metabolism as well. Type 2 Diabetes mellitus is metabolic disease of endocrine which is originated by complex action of polygenic
inheritance and environmental factor. It is strongly associated with visfatin. Visfatin has important clinical significance in developing new
biomarker and drug target for diabetes mellitus. |
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