| 冯丹1 蔡建2 张颖一1 傅强1 王雅杰1△.SPARC 结构与功能研究进展[J].,2012,12(3):560-562 |
| SPARC 结构与功能研究进展 |
| Progress of Structure and Function of SPARC |
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| DOI： |
| 中文关键词: SPARC 信号转导 生长因子 |
| 英文关键词: SPARC Signal transduction Growth factors |
| 基金项目:上海市重点学科资助项目（B905） |
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| 中文摘要: |
| SPARC(secreted protein, acidic and rich in cysteine)是一种具有多样细胞生物学功能、分布广泛的分泌性基质蛋白。具有3 个
独立模块结构，不同肽段所行使生物学功能不尽相同。除破坏细胞粘附和抑制细胞周期进程外，SPARC 还具有调节细胞分化、参
与细胞对某些生长因子反应等生理功能。SPARC 参与PI3K/AKT、MAPK、Wnt 通路的调控，并对β-FGF、VEGF、PDGF、TGFβ等
生长因子以及基质蛋白酶具有调节作用。对SPARC 功能多样性的深入研究，有助于阐明SPARC 组织特异性的作用机制。 |
| 英文摘要: |
| SPARC(secreted protein, acidic and rich in cysteine), a well-known secreted extracellular matrix-associated glycoprotein
is known to be involved in multiple biological function. SPARC is widely distributed, consisted of three peptides with multi-function.
Besides the roles in adhesion and cell cycle, SPARC also plays a role in cell differentiation and interacts with some growth factors.
SPARC is involed in several signal pathways, such as PI3K/AKT, MAPK, Wnt.SPARC also can modulate several growth factors,such as
β-FGF, VEGF, PDGF, TGFβ and MMPs. It can fully understand the specific mechanisms in different tissues through deepgoing studies
of the functions of SPARC. |
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