| 徐强1 董大海1 高丽莉2 徐文2△ 高琨2 罗芳2 侯顺利2 左晶2
刘红2 闫文2 杨银书2 卢娟2.Hsp70 对低氧大鼠海马DG 区神经细胞p53、p-p38 表达的研究[J].,2012,12(3):419-421 |
| Hsp70 对低氧大鼠海马DG 区神经细胞p53、p-p38 表达的研究 |
| The Overexpression of HSP70 of the Neurocyte in the Area of Dentate Gyrus（DG）on the p53and p-p38 of Rat's Hippocampus Under Hypoxia |
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| DOI： |
| 中文关键词: 热休克蛋白70 细胞凋亡 p53 p-p38 |
| 英文关键词: Heat shock protein 70 Apoptosis p53 p-p38 |
| 基金项目:全军重点基金课题（G-867） |
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| 中文摘要: |
| 目的：探讨热休克蛋白70（HSP70）高表达对低氧大鼠海马DG 区神经细胞p53、p-p38 表达的影响。方法：将大鼠海马DG 区
神经细胞在41℃温浴1h 诱导HSP70 高表达，然后低氧培养，Western-blot 检测细胞HSP70、p53、p-p38 的表达。结果：温浴可以诱
导HSP70 高表达；HSP70 高表达可抑制p53 和p-p38 表达。结论：HSP70 保护低氧诱导的细胞凋亡可能与抑制p53 和p-p38 表达
有关。 |
| 英文摘要: |
| Objective: To investigate the effect of the HSP70 over-expression on the p53and p-p38 of the neurocyte in the area of
dentate gyrus（DG）of rat's hippocampus under hypoxia. Methods: Neurocyte in the area of dentate gyrus（DG）of rat's hippocampus was
treated in 41℃ for 1h to induced the over-expression of HSP70.Culturing in hypoxiathe. The level of p53 and p-p38 was detected by
Western-blot. Results: Warm bath could induced the over-expression of HSP70; The overexpression of HSP70 down-regulated p53 and
p-p38. Conclusions: The over-expression of HSP70 inhibited cell apoptosis from hypoxia maybe related to the downregulating of p53 and
of p-p38. |
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