| 白翠红王维李雨婷.转化因子-β 受体III[J].,2012,12(2):385-388 |
| 转化因子-β 受体III |
| Transforming Growth Factor-β Receptor III |
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| DOI： |
| 中文关键词: TGF-β 受体III 卵巢癌 β 蛋白聚糖 |
| 英文关键词: Transforming growth factor-β receptor III Ovarian cancer Betaglycan |
| 基金项目: |
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| 中文摘要: |
| 转化生长因子-β（transforming growth factor-β，TGF-β）受体III，又称为β 蛋白聚糖（betaglycan），是一种膜锚定蛋白。TGF-β
受体III 是表达最为丰富的TGF-β 受体，曾被认为是TGF-β 超家族(包括TGF-β、激活素和抑制素等）的辅助受体。后来研究表明，
它在介导和调节TGF-β 的信号转导中具有非常重要的、不可替代的作用。它通过与TGF-β 形成复合体来介导对靶细胞的作用。
在没有TGF 配体的情况下，TGF-β 受体III 可以激活p38 信号，表明这一受体可能与不依赖TGF-β 的信号通路相互作用。TGFβ
受体III 还可以结合并调节抑制素的信号转导。TGFβ 受体III 与抑制素A 结合，形成一个稳定的高亲和复合物。体外研究表明，
TGFβ 受体III 还结合抑制素B 和强化抑制素与II 型激活素受体的关系。有关报道显示TGFβ 受体III 在卵巢癌中具有肿瘤抑制
的作用。研究表明，在上皮源性卵巢癌中,TGFβ 受体III mRNA 和蛋白质表达降低或丢失，丢失的程度与肿瘤分级相关。有很多因
素可以影响并调节该受体的表达,如雌激素、卵泡刺激素(FSH)、TGF-β1 等，深入开展相关机制的研究，对于癌症的治疗和预防将
会起到一定的推动作用。 |
| 英文摘要: |
| Transforming growth factor-β (TGF-β) receptor III, also known as betaglycan, is a membrane anchored protein.
TGF-β receptor III is the most abundant expression of TGF-β receptor, and was considered to be the coreceptor of TGF-β superfamily
(including TGF-β, activin and inhibin, etc.).Later researches show that it has a very important and irreplaceable role in mediating and
regulating TGF-β signal transduction. It mediates effects on target cells through forming a complex with TGF-β. TGF-β receptor III can
activate the p38 signal in the absence of TGF, which indicates this receptor may not rely on TGF-β signaling pathway interactions. TGF
β receptor III can bind to inhibin and regulate inhibin signal transduction. TGF β receptor III combines with inhibin A, which forming a
stable high affinity complex. In vitro studies have shown TGF-β receptor III can also combine with inhibin B and strengthen the relationship
of inhibin and activin type II receptors. Reports show TGF-β receptor III plays a tumor suppressor role in ovarian cancer. Studies
show that TGF-β receptor III mRNA and protein expression decreased or lost in epithelial ovarian cancer, and the degree of loss is associated
with tumor grade. There are many factors that can influent and regulate the expression of the receptor, such as estrogen, follicle
stimulating hormone (FSH), TGF-β1, etc. In-depth studying about the related mechanism will play a certain role for the treatment and
prevention of cancer. |
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