| 刘玉昊1 王晶2 王旭1 邵一兵1 许文亮1 惠波1 武越1.瑞舒伐他汀治疗颈动脉粥样硬化斑块的临床研究[J].,2012,12(1):123-125 |
| 瑞舒伐他汀治疗颈动脉粥样硬化斑块的临床研究 |
| Clinical Research of Rosuvastatin in Treating Carotid Atherosclerosis Plaque |
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| DOI： |
| 中文关键词: 瑞舒伐他汀 颈动脉粥样硬化 临床研究 |
| 英文关键词: Rosuvastatin Carotid atherosclerosis plaque Clinical research |
| 基金项目: |
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| 中文摘要: |
| 目的：研究瑞舒伐他汀对颈动脉粥样硬化斑块的治疗效果。方法：将在本院接受治疗的250 例颈动脉粥样硬化斑块患者随
机分成治疗组125 例和对照组125 例，治疗组服用瑞舒伐他汀10mg/ 晚，对照组行其他非瑞舒伐他汀药物治疗，进行为期6 个月
的观察对比。结果：治疗组治疗后总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白（LDL）水平显著下降，高密度脂蛋白（HDL）水平
显著升高（P＜0.05），颈动脉内膜- 中层厚度（IMT）、斑块面积变小，与治疗前比较，差异有统计学意义（P＜0.05）；对照组治疗前后
无显著性差异（P>0.05）。结论：瑞舒伐他汀对降低血脂、减缓不稳定型心绞痛早期动脉粥样硬化、稳定斑块和预防脑血管疾病起到
非常重要的作用。 |
| 英文摘要: |
| Objective: To investigate the effects of rosuvastatin on carotid atherosclerosis plaque. Methods: A total of 250 patients
with carotid atherosclerosis plaque who were therapied in our hospital average randomly divided into two groups: rosuvastatin group
(n=125) and routine therapy control group (control group, n=125). Rosuvastatin group was given rosuvastatin in 10mg per night, routine
therapy control group was given treatment without rosuvastatin. Two groups both were evaluated for 6 months. Results: The levels of TC,
TG and LDL of rosuvastatin group after treatment decreased significantly, HDL increased. IMT and area of carotid atherosclerotic plaque
decreased significantly. There was statistical significance between pretreatment and post-treatment in the rosuvastatin group(P<0.05), but
there was no obvious change in the control group(P>0.05). Conclusion: Rosuvastatin can lower blood-lipid level and prevent the progression
of early atherosclerotic plaque of unstable angina. At the same time it improves the stabilization of plaque and plays an active role in
prevention of cerebral vascular disease. |
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