| 刘盈盈1,2 杨玲1,2 杨建光1 张高1,2△.β- 淀粉样多肽低分子量寡聚体对大鼠学习记忆功能的影响[J].,2012,12(1):49-51 |
| β- 淀粉样多肽低分子量寡聚体对大鼠学习记忆功能的影响 |
| The Effect on Rat Learning and Memory of LMWAβ Oligomers |
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| DOI： |
| 中文关键词: ：β- 淀粉样多肽 低分子量寡聚体 学习记忆 |
| 英文关键词: β-amyloid peptide LMWOligomers Learning and Memory |
| 基金项目:贵州省科学技术基金(黔科合J 字[2009]2153 号)。 |
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| 中文摘要: |
| 目的：探究Aβ 低分子量寡聚体对大鼠学习记忆功能的影响；方法：双侧海马内一次性注射Aβ 低分子量寡聚体，15 天后开
始进行行为测试，测试方法采用跳台实验法、穿梭实验法和Morris 水迷宫法；结果：跳台实验结果显示，与对照组比较，Aβ 组跳台
潜伏期短，错误次数多，差异有统计学意义（P<0.05）；穿梭实验结果显示，与对照组比较，Aβ 组由明箱进入暗箱的潜伏期短，错误
次数多，差异有统计学意义（P<0.05）；水迷宫实验结果显示，与对照组比较，Aβ 组潜伏期长，跨越原平台次数少，差异有统计学意
义（P<0.01）；结论：Aβ 组大鼠学习记忆能力和空间分辨能力降低，Aβ 低分子量寡聚体在大鼠体内表现出较强的毒性作用。 |
| 英文摘要: |
| Objective: To investigate the effect of low molecular weight oligomers of β-amyloid peptide on the rat learning and
memory. Methods: LMW Aβ oligomers was microinjected into bilateral hippocampus at once. And behavioral tests were carried out after
15 days. Step-down test, Shuttle-box test and Morris water maze test were used to evaluate rat learning and memory function. Results:
Step-down test showed that the rats in Aβ made notable errors compared with the control group （P<0.05）and the incubation period
(jumping from the platform) significantly reduced（P<0.05）. Shuttle-box test showed that compared with the control group, the rats in Aβ
made notable errors （P<0.05）and the incubation period (entering in dark chamber from light chamber) significantly reduced（P<0.05）.
Morris water maze test indicated that the incubation period of finding platform significantly extended （P<0.01）and frequency passing
through the prior platform was less in Aβ group （P<0.01）. Conclusions: Microinjection of LMW Aβ oligomers into rat hip- pocampus
may induce the learning and memory dysfunction, and LWM Aβ oligomers induced an impairment in rat spatial resolution. In a word,
LWM Aβ oligomers had strong toxic effects on the rat learning and memory. |
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