| 李凡妮郭青龙.TGF-β信号通路在肿瘤侵袭转移中的作用[J].,2011,11(21):4194-4197 |
| TGF-β信号通路在肿瘤侵袭转移中的作用 |
| Effect of TGF-βPathway in Tumor Metastasis |
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| DOI： |
| 中文关键词: TGF-β 肿瘤 侵袭 转移 |
| 英文关键词: TGF-β Tumor Invasion Metastasis |
| 基金项目: |
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| 中文摘要: |
| TGF-β信号通路是一个重要的细胞内信号转导通路，能够通过影响肿瘤微环境、增强肿瘤迁移运动能力和抑制免疫细胞功
能来促进肿瘤细胞的侵袭转移。TGF-β 信号通路与肿瘤发展之间密切的联系使得TGF-β 信号转导通路成为治疗肿瘤的新靶
点。本文通过查阅近年来相关文献，概括TGF-β在肿瘤侵袭转移中所起作用的研究进展，并在此基础上对新型抗TGF-β药物治
疗进行了展望。 |
| 英文摘要: |
| Transforming growth factor-β (TGF-β) pathway is an important intracellular signal transduction pathways, it can
promote cancer metastasis through its effects on the tumor microenvironment, enhanced migration properties, and inhibition of immune
cell function. A close link between TGF-βsignaling and cancer progression has made this signaling pathway as a new therapeutic target.
In this paper, we study the correlative references of recent years, summarize the advances in the research of TGF-β's effect on tumor
metastasis. Basing on this, we prospect the research of the novel TGF-β-based therapies in the future. |
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