| 陈量孙立袁胜涛.肿瘤微环境中相关细胞的研究进展[J].,2011,11(21):4175-4177 |
| 肿瘤微环境中相关细胞的研究进展 |
| The Development of Cell in the Tumor Microenvironment |
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| DOI： |
| 中文关键词: 微环境 成纤维细胞 内皮细胞 炎症细胞 脂肪细胞 |
| 英文关键词: Microenvironment Fibroblasts Vascular endothelial cells Immune cells Lipocyte |
| 基金项目:国家自然科学基金（81071841）；十一五科技重大专项：重大新药创制(NO.2009zx09302-002) |
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| 中文摘要: |
| 肿瘤的微环境对肿瘤的发生，发展具有重要的意义。实体瘤中除肿瘤细胞外存在大量的非肿瘤细胞，如肿瘤间质细胞、成纤
维细胞、血管内皮细胞、免疫细胞、脂肪细胞等等，这一系列的细胞与肿瘤细胞相互作用，通过一系列的因子分泌而促使肿瘤的进
一步的恶化，目前传统的抗肿瘤药物研究往往局限于肿瘤细胞本身而忽略了肿瘤周围的细胞作用，使得肿瘤久治不愈。将来的药
物开发应该围绕肿瘤细胞为主体的同时，兼顾微环境中的其他细胞，多靶点治疗肿瘤，真正实现肿瘤的治愈。 |
| 英文摘要: |
| The tumor microenvironment have great significance to tumor occurrence and development , Solid tumors, in addition
to a large number of tumor there is a lot of non-tumor cells such as tumor stroma cells, fibroblasts, vascular endothelial cells, immune
cells, lipocyte, etc. This series of cells and tumor cell is interaction, through a series of secreting factor which promote further deterioration
of the tumor. Study of traditional anticancer drugs currently often limited to the tumor cells themselves but neglecting of the role of
the cells around the tumor cells, making the cancer permanently. Future drug development should focus on the tumor cells as the main
body, while taking into account other cells in the micro-environment, multi-target treatment of cancer, which was really cure the cancer. |
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