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目的：探讨血清降钙素原（PCT）作为早期诊断新生儿败血症指标的临床价值。方法：应用免疫色谱法对101 例新生儿进行 PCT水平测定，并与C反应蛋白(CRP)作比较。将患儿按出院诊断分为败血症组、一般感染组、非感染组进行分析。结果：败血症组患儿血清PCT和CRP明显高于一般感染组和非感染组，差异有统计学意义（P＜0.05）；一般感染组与非感染组血清PCT、CRP比较差异有统计学意义（P＜0.05）。以0.5ng/mL 为临界值，PCT 诊断新生儿败血症的敏感度为92.11%，特异度为78.79%；以 8.0mg/L为临界值，诊断败血症的敏感度为65.79%，特异度为69.70%。与CRP相比，PCT诊断败血症的敏感性、特异性更高。经有效抗生素治疗后，血清PCT下降幅度明显大于血清CRP下降幅度。结论：新生儿血清中PCT水平的检测对败血症的早期诊断及病情程度判断、治疗效果的评价具有重要价值。

英文摘要:

Objective: To investigate Procalcitonin （PCT）for early diagnosis of neonatal septicemia. Methods: The serum PCT levels were measured with immune chromatography（PCT-Q）assay and compared with the serum C-reactive protein （CRP）in 101 neonates. To assignment the neonates for three groups with discharage diagnosis, 101 neonates were divided into neonatal septicemia group, common infection group and non-infection group according to discharge diagnosis. Results: Serum concentrations of PCT and CRP in neonatal septicemia group were significantly higher than those common group and non-infection group （all P < 0.05）. Serum concentrations of PCT and CRP in neonates with common infection cares were significantly higher than those non-infection cares（P< 0.05）. Set 0.5ng/ml for a critical value , PCT was positive in 92.11% neonatal septicemia cases, the specificity rate was 78.79%. Set 8.0ng/ml for a critical value ,PCT was positive in 65.79% neonatal septicemia cases, the specificity rate was 69.70%. The sensitivity and specificity rate of PCT were much higher than that of CRP. The level of the serum PCT decreased rapidly during effective antibiotic therapy. Conclusions: The measurement of PCT will be very important to the early and differential diagnosis and judgment of therapeutic efficacy of neonatal infection.

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