朱江丽1 朱兵2△ 王秉林2 田广磊2.血清降钙素原检测对早期诊断新生儿败血症的临床价值[J].,2011,11(21):4126-4128 |
血清降钙素原检测对早期诊断新生儿败血症的临床价值 |
The Value of Serum Procalcitonin in the Early Diagnosis of NeonatalSepticemia |
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DOI: |
中文关键词: 降钙素原 C反应蛋白 新生儿 败血症 诊断 |
英文关键词: Procalcitonin C-reactive protein Neonatal Septicemia Diagnose |
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中文摘要: |
目的:探讨血清降钙素原(PCT)作为早期诊断新生儿败血症指标的临床价值。方法:应用免疫色谱法对101 例新生儿进行
PCT水平测定,并与C反应蛋白(CRP)作比较。将患儿按出院诊断分为败血症组、一般感染组、非感染组进行分析。结果:败血症组
患儿血清PCT和CRP明显高于一般感染组和非感染组,差异有统计学意义(P<0.05);一般感染组与非感染组血清PCT、CRP比
较差异有统计学意义(P<0.05)。以0.5ng/mL 为临界值,PCT 诊断新生儿败血症的敏感度为92.11%,特异度为78.79%;以
8.0mg/L为临界值,诊断败血症的敏感度为65.79%,特异度为69.70%。与CRP相比,PCT诊断败血症的敏感性、特异性更高。经有
效抗生素治疗后,血清PCT下降幅度明显大于血清CRP下降幅度。结论:新生儿血清中PCT水平的检测对败血症的早期诊断及
病情程度判断、治疗效果的评价具有重要价值。 |
英文摘要: |
Objective: To investigate Procalcitonin (PCT)for early diagnosis of neonatal septicemia. Methods: The serum PCT
levels were measured with immune chromatography(PCT-Q)assay and compared with the serum C-reactive protein (CRP)in 101
neonates. To assignment the neonates for three groups with discharage diagnosis, 101 neonates were divided into neonatal septicemia
group, common infection group and non-infection group according to discharge diagnosis. Results: Serum concentrations of PCT and
CRP in neonatal septicemia group were significantly higher than those common group and non-infection group (all P < 0.05). Serum
concentrations of PCT and CRP in neonates with common infection cares were significantly higher than those non-infection cares(P<
0.05). Set 0.5ng/ml for a critical value , PCT was positive in 92.11% neonatal septicemia cases, the specificity rate was 78.79%. Set
8.0ng/ml for a critical value ,PCT was positive in 65.79% neonatal septicemia cases, the specificity rate was 69.70%. The sensitivity and
specificity rate of PCT were much higher than that of CRP. The level of the serum PCT decreased rapidly during effective antibiotic therapy.
Conclusions: The measurement of PCT will be very important to the early and differential diagnosis and judgment of therapeutic efficacy
of neonatal infection. |
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