王涛秦俭王晶王长远△ 廖秋菊.尼卡地平和乌拉地尔治疗高血压急症的比较[J].,2011,11(21):4065-4068 |
尼卡地平和乌拉地尔治疗高血压急症的比较 |
Comparison of Nicardipine and Urapidil in Treatment of HypertensiveEmergencies |
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DOI: |
中文关键词: 尼卡地平 乌拉地尔 高血压急症 |
英文关键词: Nicardipine Urapidil Hypertension emergencies |
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中文摘要: |
目的:比较尼卡地平和乌拉地尔治疗高血压急症的治疗效果和不良反应。方法:选择2010 年1 月至2011 年3 月就诊于我
院的83例高血压急症患者,将其随机分为尼卡地平组42 例和乌拉地尔组41 例:尼卡地平组先给予1mg iv,然后以10-40μg/min
持续静点,然后根据血压情况调整药物剂量;乌拉地尔组先给予12.5mg iv,然后以50-200μg/ min 持续静点,然后根据血压情况调
整药物剂量;记录用药前后心率、血压情况及不良反应。结果:尼卡地平和乌拉地尔在治疗高血压急症降血压方面,两者没有发现
显著性差异(P >0.05),但治疗后尼卡地平组心率明显上升(P<0.05),乌拉地尔组心率明显下降(P<0.05)。此外,尼卡地平组的不良
反应明显低于乌拉地尔组(P<0.05)。结论:尼卡地平和乌拉地尔对高血压急症均有良好的治疗效果,但尼卡地平更加安全,不良反
应较少。 |
英文摘要: |
Objective: To observe the effect and adverse reactions in patients with hypertensive emergencies in order to compare
nicardipine with urapidil. Method: 83 patients with hypertensive emergencies who visited our hospital from Dec. 2010 to Mar. 2011 were
divided into the following two groups at random, the nicardipine group and the urapidil group. The patients in the nicardipine group
received a 1mg nicardipine injection intravenous, and 10-40μg/min intravenous transfusion was given continuous. The patients in the
urapidil group received a 12.5mg urapidil injection intravenous, and 50-200μg/ min intravenous transfusion was given continuous. We
change the dosage by the patients' blood pressure in both of the groups. The patients' blood pressure, heart rate and adverse reaction were
recorded and analyzed. Result: There was no significant difference between nicardipine and urapidil to reduce the blood pressure in treatment
patients with hypertensive emergencies (P>0.05). While in the nicardipine group, the heart rate rise after the treatment, the difference
was statistically significant (P<0.05); in the urapidil group, the heart rate goes down after the treatment, and the difference was statistically
significant (P<0.05). The nicardipine group has less adverse reactions than the urapidil group, and the difference was statistically
significant (P<0.05). Conclusion: Both of nicardipine and urapidil is effective in the treatment of hypertensive emergences, while the
nicardipine is safer and has less adverse reaction. |
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