| 石静鞠放清水汪冯丹颜芳王宁王雅杰.血浆uPA、uPAR在乳腺癌分子亚型中的表达及临床意义[J].,2011,11(21):4058-4060 |
| 血浆uPA、uPAR在乳腺癌分子亚型中的表达及临床意义 |
| The Clinical Significance of the Measuring the Plasma Level of uPA, uPARin the Molecular Subtypes of Breast Carcinoma |
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| DOI： |
| 中文关键词: 乳腺癌 uPA uPAR 分子亚型 |
| 英文关键词: Breast carcinoma uPA uPAR Molecular subtypes |
| 基金项目:上海市科学技术委员会科研技划资助项目（06DZ19505）；上海市卫生局科研计划项目（2009113） |
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| 中文摘要: |
| 目的：探讨血浆uPA、uPAR在不同分子亚型乳腺癌中的表达水平及其对乳腺癌患者治疗、预后等的临床意义。方法：采用免
疫组化ELISA方法测定的女性乳腺癌初治患者86例的血浆uPA、uPAR水平，所有患者均经组织病理学确诊，以患者的临床病理
学资料提供的免疫组化结果为基础进行分子分型，结合二者进行分析。结果：血浆uPA在乳腺癌不同分子亚型中表达有统计学差
异(P<0.01)，uPAR在乳腺癌不同分子亚型中表达有统计学差异(P<0.05)；乳腺癌患者血浆uPA和uPAR呈显著正相关（P<0.01,
Pearson 相关系数r=0.735）。结论：乳腺癌患者血浆uPA和uPAR的水平与分子亚型密切相关，他们和分子亚型联合，可能对乳腺
癌个体化治疗及判定预后有指导意义。 |
| 英文摘要: |
| Objective: To study the clinical significance of the plasma levels of uPA, uPAR in the molecular subtypes of breast
carcinoma. Methods: Using ELISA method. Measuring the plasma levels of uPA, uPAR of 84 female inpatients with breast carcinoma，
All patients visited a doctor for the first time. Results: The plasma levels of uPA, uPAR in the molecular subtypes of breast carcinoma are
different (P<0.05). The plasma levels of uPA have a hingh relation with uPAR in breast carcinoma（P<0.01,r=0.735.）Conclusion: The
plasma levels of uPA, uPAR in the patients with breast carcinoma were corelated with the molecular subtypes. Combined the detection of
the plasma levels of uPA, uPAR whith the molecular subtypes may heplefull for the individualized treatment and estimating prognosis. |
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