| 朱静孙立袁胜涛.B 淋巴细胞刺激因子（BLyS）调控相关蛋白的研究进展[J].,2011,11(20):3972-3974 |
| B 淋巴细胞刺激因子（BLyS）调控相关蛋白的研究进展 |
| Relative Proteins Involved in Regulation of B Lymphocyte Stimulator(BLyS) |
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| DOI： |
| 中文关键词: BLyS 调控 自身免疫疾病 |
| 英文关键词: BLyS regulations autoimmune disease |
| 基金项目: |
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| 中文摘要: |
| B 淋巴细胞刺激因子是肿瘤坏死因子超家族的成员之一，它同自身免疫疾病的发生发展密切相关，BLyS 过度表达会促使B
淋巴细胞增殖并分泌自身抗体。BLyS 也是治疗自身免疫疾病的重要靶点。关于BLyS 的调控涉及了许多蛋白。本文主要就
G-CSF、TGF-β1、IFN-γ、IL-10 和Poly(I:C)等对BLyS 的调控作用作一综述。 |
| 英文摘要: |
| Blymphocyte stimulator, a member of tumor necrosis factor super family, is relative to nosogenesis and progression of
autoimmune diseases. Overexpression of BLyS would promote proliferation of B cells and secration of autoantibodies. BLyS is also
regarded as an important target of autoimmune diseases. Many proteins are involved in the regulation of BLyS. We now have a summary
on several proteins which play roles in regulation of BLyS, such as G-CSF, TGF-β1, IFN-γ, IL-10, Poly(I:C) and so on. |
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