| 李飞凤周建华△ 胡永斌.核转录因子Snail 调控上皮- 间质转型机制的研究[J].,2011,11(20):3961-3963 |
| 核转录因子Snail 调控上皮- 间质转型机制的研究 |
| Mechanism of Transcriptional Factor Snail on Epithelial-MesenchymalTransition* |
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| DOI： |
| 中文关键词: Snail 纤维化 肿瘤 上皮- 间质转化 |
| 英文关键词: Snail Fibrosis Tumor Epithelial-mesenchymal transition (EMT) |
| 基金项目:国家自然科学基金(30700661)；湖南自然科学基金(06JJ2098)。 |
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| 中文摘要: |
| 上皮- 间质转型在纤维化及肿瘤侵袭转移中发挥着重要作用，多种因子作用于核转录因子Snail 诱导细胞通路改变，以实现
对上皮- 间质转型进行调控。因此对Snail 调控上皮- 间质转化信号转导机制的研究，为发展新的治疗策略提供了重要信息。 |
| 英文摘要: |
| Epithelial cells serve as an important source of myofibroblasts through epithelial-mesenchymal transition (EMT) in
fibrosis and tumor invasion and metastasis. Several factors act on snail and regulate the process of EMT. The studies on mechanism of
transcriptional factor snail on epithelial-mesenchymal transition can supply important information for therapeutic strategy. |
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