| 倪田根1 祝秉东2 周欣1 王娜1 曾峰3 关泉林1.胃癌组织中ENO1、M2-PK 蛋白表达及其临床意义[J].,2011,11(20):3871-3874 |
| 胃癌组织中ENO1、M2-PK 蛋白表达及其临床意义 |
| Expressions and Clinical Significances of ENO1 and M2-PKin Gastric Cancer |
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| DOI： |
| 中文关键词: 胃癌 烯醇化酶-α 肿瘤型丙酮酸激酶 免疫组化 肿瘤转移 |
| 英文关键词: Gastric cancer Enolase-α Tumor M2 pyruvate kinase Immunohistochemistry |
| 基金项目:中央高校基本科研业务费专项资金资助(lzujbky-2010-143) |
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| 中文摘要: |
| 目的：探讨胃癌组织中烯醇化酶-α（enolase-α,ENO1)、肿瘤型丙酮酸激酶(tumor M2 pyruvate kinase,M2-PK)的表达、相互关
系及临床病理学意义。方法：应用免疫组织化学SP 染色方法分别对55 例胃癌组织和23 例胃良性病变组织切片染色，观察胃癌
组织和良性病变组织ENO1、M2-PK 的表达情况及分析两者临床病理关系。结果：胃癌组织中ENO1 阳性表达率为67.3% (37／
55)，明显高于胃良性病变组30.4%(7／23) ( P<0.01)，其表达与胃癌分化程度、浸润深度、淋巴结转移及TNM 分期均显著相关(均
P<0.05)。M2-PK 在胃癌组织中的阳性表达率为78.2%(43／55)，明显高于胃良性病变组织39.1%(9／23) ( P<0.01)，其表达与胃癌
分化程度、浸润深度均显著相关(均P<0.05)。胃癌组织中ENO1 与M2-PK 的表达呈正相关(r=0.5729，P<0.05)。结论：ENO1 和
M2-PK 的表达上调与胃癌的发生、发展可能有关，联合检测两种蛋白在肿瘤组织中的表达，对临床判断胃癌的预后有一定的指导
意义。 |
| 英文摘要: |
| Objective: To investigate the expression and clinicopathological significance of enolase-α (ENO1) and tumor M2
pyruvate kinase (M2-PK) in gastric cancer. Methods: The expression of ENO1 and M2-PK in 55 paraffin-embedded specimens of gastric
cancer and 23 paraffin-embedded specimens of benign gastric tissue was detected by S-P immunohistochemistry. The correlation of
ENO1 expression to M2-PK expression , and their correlations to the clinicophathologic features of gastric cancer were analyzed. Results:
The positive rate of ENO1 was significantly higher in gastric cancer than in benign gastric tissue (67.3% vs . 30.4%, P<0.01) , and
closely related to differentiation grade ( P<0.01) , depth of invasion (P<0.01), lymph node metastasis (P<0.05) and TNM staging( P<0.
05).The positive rate of M2-PK was significantly higher in gastric cancer than in benign gastric tissue (78.2%vs . 39.1%, P<0.01) , and
closely related to differentiation grade ( P<0.05) , depth of invasion ( P<0.05) .The expression of ENO1 was positively correlated to that
of M2-PK (r=0.5729，P<0.05) . Conclusion: The up-regulation of ENO1 and M2-PK expression may play important roles in the
oncogenesis and progression of gastric cancer. Combined detection of the expression of ENO1 and M2-PK in gastric cancer may provide
a significant parameter to judge the clinical prognostic of gastric cancer. |
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