| 董学海1,2 肖骏2 李先涛1.双孔钾通道TASK-1 的研究进展[J].,2011,11(19):3790-3793 |
| 双孔钾通道TASK-1 的研究进展 |
| Research progress of K2P channel TASK-1 |
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| DOI： |
| 中文关键词: 双孔钾离子通道 TASK-1 功能 |
| 英文关键词: K2P channel TASK-1 Functions |
| 基金项目:湖北省卫生厅青年科技人才基金(QJX2008-5) |
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| 中文摘要: |
| 双孔钾离子通道是一种背景钾离子通道，广泛分布于各种兴奋和非兴奋细胞中，并具有许多重要的生理功能。TASK-1 是双
孔钾离子通道家族的重要一员，它对缺氧和细胞外酸化敏感，参与形成心肌动作电位平台期，调节呼吸、肺动脉平滑肌收缩和醛
固酮的分泌，并且是麻醉剂的作用靶点，人们不断对其进行研究并取得了很多重要结果，本文将概述双孔钾通道TASK-1 的研究
进展。 |
| 英文摘要: |
| The two-pore domain potassium channel (K2P) is a background channel, which is widely distributed in excited and
unexcited cells, and plays important physiological roles in those cells. TASK-1 channel is a member of K2P family and sensitive to hypoxia
and extracellular acidosis. The acid-sensitive channel substantially contributes to the outward current flowing in the plateau range
ofaction potentials.TASK-1 channelmaydetermine the contractile and electrophysiological properties of pulmonary artery smoothmuscle. It
also regulates respiration and secretion of aldosterone and is a target of anesthetics. Background TASK-1 channel was deeply investigated
by researcher and lots of data were accumulated. The review described recent research progress of K2P channel TASK-1. |
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