文章摘要
高应东1 夏永祥1 张瑞生1 朱成宾1 赵昕亚1 肖平喜2.血浆IIA 分泌型磷脂酶A2 水平与冠脉支架术后再狭窄关系[J].,2011,11(19):3666-3668
血浆IIA 分泌型磷脂酶A2 水平与冠脉支架术后再狭窄关系
Relationship Between Plasma IIA Secretory Phospholipase A2 andRestenosis after Percutanous Coronary Intervention in Patients withCoronary Heart Disease
  
DOI:
中文关键词: ⅡA 分泌型磷脂酶A2  高敏C- 反应蛋白  支架植入术  再狭窄
英文关键词: Group IIA secretory phospholipase A2  High sensitive C-reactive protein  Percutanous coronary intervention  Restenosis
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高应东1 夏永祥1 张瑞生1 朱成宾1 赵昕亚1 肖平喜2 南京医科大学附属南京第一医院1.检验科2.心内科 
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中文摘要:
      目的:测定稳定型冠心病患者支架植入术(percutanous coronary intervention ,PCI)前血浆IIA 分泌型磷脂酶A2(group IIA secretory phospholipase A2,ⅡA-sPLA2)的水平,以探讨该酶与冠脉支架术后再狭窄的可能关系。方法:稳定型冠心病行PCI 患者 63 例,非冠心病患者39 例,健康正常对照组42 例,分别取外周静脉血测定血浆ⅡA-sPLA2 酶浓度。PCI 患者6 个月后复查造影。 结果:PCI 患者术前该酶浓度显著高于正常对照组(P<0.05),支架内再狭窄率34.9 %,再狭窄(restenosis,RS)患者支架术前该酶水 平与无再狭窄患者该酶水平无统计学差异(P>0.05)。结论:PCI 患者术前血浆ⅡA-sPLA2 酶浓度显著高于正常对照组,但可能与 支架术后再狭窄无关。
英文摘要:
      Objective: To study the correlation between IIA-sPLA2 level and restenosis after percutanous coronary intervention (PCI) in Patients with coronary heart disease. Methods: This study enrolled 63 patients with coronary heart disease (CHD) who underwent successful PCI,39 patients with non-CHD, and 42 healthy subjects were studied as a control group .Levels of IIA-sPLA2 in plasma were measured by an enzymoimmunoassay using a monoclonal antibody. The patients who underwent PCI had repeat angiography at six-month follow-up. Results: The level of IIA-sPLA2 in PCI patients was significantly higher than that in healthy subjects (P<0.05), but not higher than that in patients with non-CHD (P>0.05). Restenosis occurred in 22 patients (34.9 %). While there were no significantly changes of the levels of IIA-sPLA2 between the patients without or with restenosis. Conclusions: The level of IIA-sPLA2 in patients with coronary heart disease had a significant increase compared to the healthy subjects, but such increase may not be associated with in-stent restenosis.
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