| 宋晓玲1 李青1 杨毓琴2.人附睾蛋白4 在卵巢癌中的研究进展[J].,2011,11(18):3583-3585 |
| 人附睾蛋白4 在卵巢癌中的研究进展 |
| The Progress of Human Epididymis Protein 4 in Ovarian Cancer |
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| DOI： |
| 中文关键词: 卵巢癌 CA125 抗原 附睾蛋白4 |
| 英文关键词: Ovarian cancer CA-125 antigen Human epididymis protein 4 |
| 基金项目: |
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| 中文摘要: |
| 卵巢癌是严重威胁女性健康的恶性疾病之一。糖类抗原125（carbohydrate antigen125,CA125）是目前临床上广泛用于诊断卵
巢上皮性癌的肿瘤标记物，然而其缺乏敏感性和特异性，因此，迫切需要寻找一种新的标志物来提高卵巢癌的诊断。人附睾蛋白4
（human epididymis protein 4,HE4）是近年发现的肿瘤标志物，其在良性肿瘤和正常组织中含量极低，但在卵巢癌中高表达。本文就
HE4 在卵巢癌中的诊断，动态监测等方面的进展做一综述。 |
| 英文摘要: |
| Ovarian cancer is a serious threat to the health of a malignant disease of women. Currently, the carbohydrate antigen
125(CA125) is widely accepted as clinical tumor marker for epithelial ovarian cancer, but it is lack of sensitivity and specificity, therefore, it
needs to find a new mark to improve the diagnosis of ovarian cancer urgently. The human epididymis protein 4(HE4) is discovered
recently, it is very low in benign tumors and normal tissues, but highly expressed in ovarian cancer. The research progress of HE4 in diagnosis
and dynamic monitoring of ovarian. |
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