| 张大明1 李春梅2△ 王凤军3 侯晓华3 韩占强1.伴海马硬化的颞叶癫痫患者海马组织内BDNF 表达变化[J].,2011,11(18):3555-3557 |
| 伴海马硬化的颞叶癫痫患者海马组织内BDNF 表达变化 |
| Expression of BDNF in Hippocampi Resected from Patients with TemporalLobe Epilepsy Associated with Hippocampal Sclerosis |
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| DOI： |
| 中文关键词: 颞叶癫痫 海马硬化 脑源性神经营养因子 |
| 英文关键词: Temporal Lobe Epilepsy Hippocampal Sclerosis Brain Derived Neurotrophic Factor |
| 基金项目: |
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| 中文摘要: |
| 目的：研究伴海马硬化的难治性颞叶癫痫（TLE）患者海马组织内脑源性神经营养因子（brain derived neurotrophic factor,BDNF）的
表达变化，探讨其在难治性颞叶癫痫发病机制中的作用。方法：采集5 例伴海马硬化的难治性TLE 患者手术中切除的海马组织，
用逆转录- 聚合酶链反应(RT-PCR)法检测BDNF mRNA 表达，并与3 例非海马硬化TLE 患者对照。结果：与非海马硬化组比较，
伴海马硬化的难治性TLE 患者海马组织中的BDNF mRNA 表达明显增加(P<0.01)。结论：伴海马硬化的难治性TLE 患者海马组
织中BDNF mRNA 表达表达增高，可能在海马硬化和难治性颞叶癫痫发生、发展中具有重要作用。 |
| 英文摘要: |
| Objective: To study the expression of brain derived neurotrophic factor (BDNF) in hippocampi resected from patients
with intractable temporal lobe epilepsy (TLE) associated with hippocampal sclerosis and discuss its function in the pathogenesis. Methods:
Reverse transcription polymerase chain reaction (RT-PCR) were used to test the expression of BDNF mRNA in the surgically removed
hippocampus tissue from 5 patients with intractable TLE associated with hippocampal sclerosis, and the results were compared with the
data from 3 patients with intractable TLE without hippocampal sclerosis. Results: Expression of BDNF mRNA were significantly increased
in hippocampus tissue (P<0.01) resected from patients with intractable TLE associated with hippocampal sclerosis compared with
that of controls. Conclusions: The results indicate that the expression of BDNF mRNA increases in the hippocampi of patients with intractable
TLE associated with hippocampal sclerosis, and it may play an important role in the generation and development of hippocampal
sclerosis and intractable TLE. |
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