| 马瑞风王丽岩△ 贺立新汪宇.AnnexinⅠ在PCOS 大鼠颗粒细胞中的表达及意义[J].,2011,11(18):3433-3437 |
| AnnexinⅠ在PCOS 大鼠颗粒细胞中的表达及意义 |
| Expression and Significance of AnnexinⅠin Granulosa Cells of Rats withPolycystic Ovarian Syndrome |
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| DOI： |
| 中文关键词: 多囊卵巢综合征 卵泡 颗粒细胞 膜联蛋白Ⅰ |
| 英文关键词: Polyceysntic ovarian syndrome Follicle Granulosa cell AnnexinⅠ |
| 基金项目:内蒙古自治区卫生厅科技项目(NJZY2010224) |
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| 中文摘要: |
| 目的：探讨膜联蛋白Ⅰ（AnnexinⅠ）在多囊卵巢综合征（PCOS）大鼠卵泡颗粒细胞的表达及生物学意义。方法：采用免疫组织
化学方法及灰度值测定AnnexinⅠ在PCOS 组和对照组的卵泡颗粒细胞中的表达。结果：AnnexinⅠ在两组中的各级卵泡颗粒细
胞中均有表达，PCOS 组AnnexinⅠ在窦状卵泡中表达显著高于对照组(P<0.05)。结论：PCOS 组AnnexinⅠ在窦状卵泡颗粒细胞的
表达上调，且PCOS 中窦状卵泡颗粒细胞的凋亡增加，说明AnnexinⅠ参与了卵巢颗粒细胞的凋亡过程，并且发挥了重要作用。 |
| 英文摘要: |
| Objective: To study the expression and biological significance of annexinⅠ in the granulosa cell of polycystic ovarian
syndrome (PCOS) in rat model. Methods: The expression of annexin Ⅰ was detected by immunohistochemical method, and the
quantitative analysis was performed by the gray value in PCOS and control group. Results: The annexinⅠexpressed in different classes
of preantral follicles in both PCOS group and control group. When the diameter of the follicle reached to 60~120μm, the annexin Ⅰ
expression had significant difference between the PCOS group and control group (P<0.05). Conclusion: The annexin Ⅰ expression
evidently increased in sinusoid follicle and the granulosa cell of apoptosis raised in PCOS group，which illuminated annexinⅠpaticipated
in the process of apoptosis in granulosa cell and played an immportant role. |
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