| 陈作强赵仙先△ 秦永文陈少萍郑兴.血浆脑钠肽对不同年龄急性冠脉综合征患者介入治疗术后
临床预后的意义[J].,2011,11(17):3280-3283 |
| 血浆脑钠肽对不同年龄急性冠脉综合征患者介入治疗术后
临床预后的意义 |
| The Clinical Prognostic Significance of Plasma Brain Natriuretic Peptidein Different Age Patients With Acute Coronary Syndromes UnderwentPercutaneous Coronary Intervention |
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| DOI： |
| 中文关键词: 脑钠肽 急性冠脉综合征 经皮冠脉介入 预后 |
| 英文关键词: Brain natriuretic peptide Acute coronary syndromes Percutaneous coronary intervention Prognosis |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨并比较血浆脑钠肽（BNP）对不同年龄组急性冠脉综合征（ACS）患者经皮冠脉介入（PCI）术后临床主要不良心脏
事件（MACE）的预测价值。方法：回顾分析2007 年12 月至2010 年3 月因ACS 在我院行PCI 的患者，分为≥60 岁和＜60 岁两
组，入院常规检验BNP，随访住院期间及出院后6 个月内MACE（包括死亡、心源性休克、再发心绞痛、非致命性再次心肌梗死、非
致命性心力衰竭、心律失常、靶血管血运重建、再次入院复合终点）的发生情况。结果：随访269 例≥60 岁患者，失访7 例(2.6%),
118 例＜60 岁患者，失访3 例（2.5%），。262 例≥60 岁患者的年龄与BNP 水平显著正相关（r=0.368，P＜0.01），而115 例＜60 岁患
者无显著相关性（r=-0.014，P＞0.05）。年龄≥60 岁患者BNP 水平与＜60 岁患者比较，差异显著（P＜0.01），年龄≥60 岁患者
MACE 与＜60 岁患者比较，差异显著（P＜0.01），两组患者BNP 水平与LVEF 呈显著负相关（P 均＜0.01）。多因素logistic 回归分
析显示：BNP 可独立预测两组患者住院期间及出院后6 个月内MACE（≥60 岁OR=4.369 P＜0.01；＜60 岁OR=7.773 P＜0.01）
发生率。两组患者BNP 水平对MACE 预测的ROC 曲线结果比较，差异无统计学意义（P＞0.05）。结论：不同年龄患者BNP 水平
及MACE 发生率存在差异，但年龄并不影响BNP 对ACS 患者临床预后的预测价值。 |
| 英文摘要: |
| Objective: To investigate and compare the clinical prognostic value of major abnormal cardiac events (MACE) in different
age groups of acute coronary syndrome (ACS) patients after percutaneous coronary intervention (PCI )by plasma brain natriuretic
peptide （BNP）. Methods: Reteospective analysis ACS patients after PCI from December 2007 to March 2010 in our hospital who were
divided into two age groups between ≥ 60 -year-old and ＜60-year-old, to routine test BNP and follow-up MACE (including death, cardiogenic
shock, recurrent angina pectoris, non-fatal re-infarction, non-fatal heart failure,arrhythmia, target vessel revascularization, re-admitted
to hospital composite end point) during hospitalization and within 6 months after discharge from hospital. Results: Follow-up 269
patients whose age ≥ 60 -year-old, lost 7 cases (2.6%), 118 patients whose age <60-year-old had lost 3 (2.5%),. 262 patients ≥
60-year-old between age and BNP levels were significantly positively correlated （r=0.368 P＜0.01）；while 115 cases whose age
<60-year-old between age and BNP levels were no significant correlation （r=-0.014 P＞0.05）. The difference of BNP levels compared
between age ≥ 60 -year-old and age<60-year-old was significant (P <0.01). The difference of MACE compared between age ≥ 60
-year-old and age<60-year-old was significant (P <0.01). Two groups of patients with BNP levels and LVEF was significantly negatively
correlated（both P＜0.01）. Multivariate logistic regression analysis showed that BNP may be independent predict MACE（≥ 60-year-old
OR=4.369 P＜0.01；＜60-year-old OR=7.773 P＜0.01）incidence in different age groups of patients during hospital and within 6 months
after discharge from hospital. MACE ROC curve results of two groups of patients predicted by BNP levels showed the difference was not
significant (P>0.05). Conclusion: BNP levels and MACE in patients with different ages are different, but age does not affect the prognostic
value of patients with ACS by BNP . |
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