任建鸿郑文谢彦崔建涛1 宋玉琴李忠武2 时云飞2 林宁晶王小沛
涂梅峰应志涛平凌燕刘卫平邓丽娟张晨朱军.北京大学临床肿瘤学院、北京肿瘤医院暨北京市肿瘤防治研究所淋巴肿瘤科,恶性肿瘤
发病机制及转化研究教育部重点实验室,1 肿瘤分子生物学实验室,2 病理[J].,2011,11(17):3275-3279 |
北京大学临床肿瘤学院、北京肿瘤医院暨北京市肿瘤防治研究所淋巴肿瘤科,恶性肿瘤
发病机制及转化研究教育部重点实验室,1 肿瘤分子生物学实验室,2 病理 |
The Expression of Receptor Interaction Protein-3 in Lymphoma PatientsPathology Organization |
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DOI: |
中文关键词: RIP3 淋巴瘤 病理 免疫组化 |
英文关键词: RIP3 Lymphoma Pathology Immunohistochemmistry |
基金项目: |
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中文摘要: |
目的:探讨RIP3(受体相互作用蛋白-3)在淋巴瘤患者病理组织中是否表达及其亚细胞定位,并初步观察RIP3 的表达是否
与淋巴瘤病理恶性度相关。方法:(1) 利用免疫组化技术检测48 例淋巴瘤和非肿瘤侵润淋巴结病理组织中RIP3 表达,并观察
RIP3 亚细胞定位。结果:(1)RIP3 在淋巴瘤患者病理组织中均有表达,其亚细胞定位主要在细胞核,在细胞质中相对弱表达。(2)
RIP3 表达与淋巴瘤病理恶性度可能存在相关性。结论:RIP3 在淋巴瘤患者病理组织中存在阳性表达,为研究RIP3 是否与淋巴瘤
的发病、临床表现和预后相关,提供了新的探索途径。 |
英文摘要: |
Objective: To investigate the expression of RIP3 (receptor interaction protein-3) in lymphoma patients pathological tissues
and the sub-cellular localization, and to investigate the relationship of the expression of RIP3 and malignant degree of lymphoma.
Methods: The RIP3 expression in 48 cases of the lymphoma and non-neoplastic lymph node pathological tissues was detected by immunohistochemmistry,
and the sub-cellular localization of RIP3 was observed. Results: 1) There were RIP3 expresses in the lymphoma
pathological tissues, which mainly located in nucleus but weekly in cytoplasm. 2) The expression of RIP3 had a relationship with malignant
degrees of lymphoma. Conclusion: There was RIP3 expression in lymphoma pathological tissues, which shell new light to the study
of mechanism of lymphoma. |
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