| 李泽夏刘海玲吕辉吴晓英.与卵巢癌转移有关的microRNA 研究进展[J].,2011,11(14):2793-2796 |
| 与卵巢癌转移有关的microRNA 研究进展 |
| Research of microRNA Related to Metastasis of Ovarian Cancer |
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| DOI： |
| 中文关键词: 卵巢癌 肿瘤转移 microRNAs |
| 英文关键词: Ovarian neoplasms Neoplasm metastasis MicroRNAs |
| 基金项目: |
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| 中文摘要: |
| 卵巢癌是女性生殖系统三大恶性肿瘤之一，其致死率居于各类妇科肿瘤之首，是严重影响妇女生命的重要疾患，卵巢癌的
转移则是造成病人死亡的重要因素。近年来随着microRNA（又称miRNA 或微RNA）作为一种小分子非编码RNA 被发现，证实
miRNA 的作用与各类肿瘤有着重要的联系，这些肿瘤包括乳腺癌、食管癌、胰癌、口腔癌等。近几年的研究表明，miRNA 可以影响
卵巢癌的发生与发展，并与其转移也存在着紧密的关系。与卵巢癌转移有关的miRNA 作用机制的揭示，将会为转移性卵巢癌的
诊断及治疗提供新的途径。本综述在通过检索近年来最新文献的基础上，对于卵巢癌的转移机理进行了详尽的分析，并对miRNA
在卵巢癌转移中的重要研究予以了详细的阐述。 |
| 英文摘要: |
| As one of the three major malignant tumors concerning the female reproductive system, ovarian cancer's lethality is
the leading cause of death from gynecologic cancers. It severely affects women's lives. The metastasis of Ovarian cancer is an important
factor in causing deaths. MicroRNA's (miRNA) are a recently discovered class of Small molecule and noncoding RNA's. There is a Significant
relationship between microRNAs and various types of cancer, these tumors include breast cancer, esophageal cancer, pancreatic
cancer, oral cancer, etc. In recent years, some studies have shown that miRNA could have a great influence on the occurrence and development
of ovarian cancer, and also on the metastasis of Ovarian cancer. If miRNA mechanism was revealed to be related to the metastasis
of ovarian cancer,it would provide a new approach to the diagnosis and treatment of metastatic ovarian cancer.Based on the latest
literature, this review is a detailed analysis on the metastatic mechanism of ovarian cancer and the role of miRNA within it. |
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