| 赵丽敏1 薄永青2 郭莉1 赵玲1 赵腾1 王晓红2.Kiss-1 及MVD 在非小细胞肺癌中检测的临床意义及其相关性研究[J].,2011,11(14):2677-2680 |
| Kiss-1 及MVD 在非小细胞肺癌中检测的临床意义及其相关性研究 |
| Detections of Kiss-1 and MVD in Non Small Cell Lung Cancer and TheirClinical Significance |
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| DOI： |
| 中文关键词: kiss-1 MVD 非小细胞肺癌 免疫组化 |
| 英文关键词: NSCLC Kiss-1 MVD Immunohistochemisty |
| 基金项目: |
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| 中文摘要: |
| 目的：测定NSCLC 组织中kiss-1 基因表达、MVD 分布，探讨其临床意义及其相关性。方法：应用免疫组化SP 法检测56 例
NSCLC 组织中Kiss-1 表达及MVD 分布情况，分析其与NSCLC 的临床病理参数的关系及其相关性。结果：kiss-1 在NSCLC 表
达低于对照组（P<0.05），MVD 在NSCLC 分布明显高于对照组(P<0.05)。Kiss-1 与NSCLC 的临床分期、淋巴结转移、肿瘤大小有
关(P<0.05)。MVD 与NSCLC 分化程度、临床分期及淋巴结转移、肿瘤大小有关(P<0.05).Kiss-1 阳性组MVD 分布明显低于
Kiss-1 阴性表达组，二者呈负相关(P<0.05，r=-0.363)。结论：Kiss-1 及MVD 在非小细胞肺癌发生、发展中发挥重要作用，二者存在
相关性，联合检测可帮助预测NSCLC 的侵袭、转移，判断预后。 |
| 英文摘要: |
| Objective: To detect the expressions of kiss-1 and distribution of MVD in non small cell lung cancer,to investigate
their clinical significance and associativity. Methods: The expressions of kiss-1 and distribution of MVD were detected in 56 non small
cell lung cancer by immunohistochemical SP method. Results: In non small cell lung cancer，express of kiss-1 is lower than control group
(P<0.05).Distribution ofMVD is super than control group (P<0.05). Kiss-1 is concerned with clinical stageand ,metastasis of lymph nodes
in NSCLC P<0.05), and MVD is concerned with differentiated level and clinical stageand and metastasis of lymph nodes in NSCLC
(P<0.05). Distribution of MVD in the expression positive rate of kiss-1 is higher than that in the expression negative rate of kiss-1 in the
tissue of NSCLC,they have negative correlation( P<0.05,r=-0.363). Conclusions: Kiss-1 and MVD have important role in occurrence and
progress of NCSCL. We can predict invasion, metastasis and prognosis of NSCLC by uniting detection kiss-1 and MVD. |
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