| 同李平1 袁世发1,2 丰帆1 杨建军1 张洪伟.食管鳞癌组织中的神经纤维分布[J].,2011,11(14):2635-2638 |
| 食管鳞癌组织中的神经纤维分布 |
| Nerve Fiber Distribution in Esophageal Squamous Cell Carcinoma |
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| DOI： |
| 中文关键词: 食管鳞癌 神经纤维 GAP-43 免疫组化 |
| 英文关键词: ESCC Nerve fiber GAP-43 Immunohistochemistry |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨食管鳞癌组织中神经纤维的分布情况。方法：应用免疫组化ABC 法，探查手术切除的食管鳞癌组织里S100 及
GAP-43 阳性神经纤维的分布情况，并分析其与患者临床病理参数的关系。结果：相对于正常组织，食管鳞癌组织中存在相当数量
的S100 及GAP-43 阳性神经纤维（束）不规则地分布于肿瘤细胞之间，且S100 阳性纤维密度大于GAP-43 阳性纤维密度；统计分
析显示肿瘤组织中纤维密度与患者的肿瘤大小、淋巴结转移相关。结论：食管鳞癌组织中确实存在神经纤维分布，并对肿瘤发展
起一定作用。 |
| 英文摘要: |
| Objective: The aim of this study was to investigate the arrangement and pathological significance of immunoreactive
nerve fibers in the tumor mass of human esophageal squmous cell carcinoma (ESCC). Methods: Frozen sections were processed for immunohistochemistry
staining to detect the distribution of the intratumoral nerves visualized by antibodies against S100 and growth associated
protein 43 (GAP-43). Results: The microscopic observations revealed plenty of S100 positive fibers and relatively minor GAP-43
positive fibers in the intratumoral zone. The statistical analysis demonstrated a significantly association between the two kinds of nerve
fiber and grade of tumor invasion. Conclusion: Our results indicated a novel concept that nerve fibers were really existed in the tumoral
area and some of them were regenerated. In addition, the distribution of nerve fibers was correlated with the depth of tumor invasion. |
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