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目的：研究复方α- 酮酸对维持性血液透析（MHD）患者营养及脂质代谢的影响。方法：将40 例MHD 患者随机分为两组：（1）实验组（n=20），予常规蛋白饮食, 并服用复方α- 酮酸12 片/d;（2）对照组（n=20），予常规蛋白饮食，不服用复方α- 酮酸。分别于治疗前、治疗后3 个月后测定各项血生化指标及人体测量学指标。结果：经3 个月治疗后，实验组血白蛋白、前白蛋白较前明显升高（P＜0.01），总胆固醇和甘油三酯明显下降（P＜0.01），血红蛋白无明显变化（P＞0.05）；对照组血红蛋白、血白蛋白、前白蛋白及血脂无明显变化；实验组及对照组治疗前后体重指数、肱三头肌皮褶厚度、上臂肌围无明显变化（P＞0.05）。结论：复方α- 酮酸可有效改善维持性血液透析患者营养状况以及脂质代谢，但长期使用该疗法的疗效和安全性有待于进一步的研究。

英文摘要:

Objective: To explore the effect of nutrition status and lipid metabolism in maintenance hemodialysis patients treated with compound α-keto acids. Methods: 40 hemodialysis patients were divided into two groups: (1)experimental group (n=20), were treated with common protein diet and α-keto acids 12/d α-keto acids; (2)control group (n=20), were treated with common protein diet and without α-keto acids. Measure the biochemical parameters and anthropometry measurements before and after the three months' treatment. Results: After three months' treatment, the concentrations of albumin, pro-albumin were higher in experimental group (P＜ 0.01) and cholesteral, triglyceride decreased (P＜0.01) significantly, there was no significant changes of hemoglobin. Meanwhile there was no significant changes of hemoglobin, albumin, pro-albumin, cholesteral and triglyceride in control group. No significant difference existed in body mass index, triceps skinfold, middle arm muscle circumference of the two groups before and after the treatment. Conclusion: The nutritional status and lipid metabolism of maintenance hemodialysis patients could be improved after treated with α-keto acids, but the further study is expected to testify the efficacy and safety of long-term treatment.

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