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目的：探讨热休克蛋白70(HSP70)和P53 蛋白在甲状腺乳头状癌组织中的表达及其与临床病理特征的关系。方法：应用免疫组织化学Envision 法检测35 例甲状腺乳头状癌组织、15 例甲状腺良性病变组织及15 例正常甲状腺组织中HSP70 和P53 蛋白的表达，分析HSP70 和P53 蛋白的表达与甲状腺乳头状癌临床病理学特征的关系。结果：甲状腺乳头状癌组织中HSP7O 和P53 阳性表达率明显高于甲状腺良性病变组织及正常甲状腺组织(P<0.01)。HSP7O 在甲状腺乳头状癌组织中的表达与是否有颈部淋巴结转移、浸润深度以及AJCC 分期密切相关(P<0.01),而与年龄、性别、肿瘤的大小以及分化程度无关（P＞0.05）。P53 在PTC 组织中的表达与组织分化程度、是否有淋巴结转移、浸润深度以及AJCC 分期密切相关(P<0.01), 而与年龄、性别、肿瘤的大小无关（P＞0.05）。HSP70 和P53 蛋白在PTC 组织中的表达呈正相关性(r=0.679，P<0.01)。结论：HSP70 和p53 蛋白在PTC 中均呈高表达，并有协同作用,两者可作为预测PTC 的生物学行为和预后的参考指标。

英文摘要:

Objective: To investigate the relationship of the expression of HSP70 and p53 with the pathological characteristic in papillary thyroid carcinoma. Methods: The expression of HSP70 and p53 protein were detected with immunohistochemical EnVision plus non-hiotin technique in 35 cases of papillary thyroid carcinoma,15 cases of benign thyroid diseases and 15 cases of normal tissues of thyroid．Results: The positive expression rates of HSP70 and p53 protein in papillary thyroid carcinoma were significantly higher than that in benign thyroid diseases and normal tissues of thyroid (P<0.01). The expression of HSP70 was positively related to lymph node metascasis, AJCC clinical stage and the degree of infiltration (P<0.01). The expression of p53 was positively related to AJCC clinica1 stage, differentiation degree, lymph node metascasis and the degree of infiltration (P<0.01). The expression of HSP70 was positiye1y correlated with p53 (r=0.679，P<0.01). Conclusion: The expression of HSP70 and p53 protein in papillary thyroid carcinoma were high. There was the synergistic effect between HSP70 and p53. HSP70 and p53 protein may act as markers predicting biological behavior and prognosis of papillary thyroid carcinoma.

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