| 李春晓1 魏立2△ 杨志宏2 刘志涛2 侯靓亮2.血小板膜糖蛋白(GP)Ⅲa PLA、Ⅰa807C/T 基因多态性与阿司匹林
抵抗的相关性研究[J].,2011,11(12):2324-2327 |
| 血小板膜糖蛋白(GP)Ⅲa PLA、Ⅰa807C/T 基因多态性与阿司匹林
抵抗的相关性研究 |
| Relationship Between the Gene Polymorphisms of Platelet Glycoprotein ⅢaPLA and Ⅰa807C/T with Aspirin Resistance |
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| DOI： |
| 中文关键词: 阿司匹林抵抗 血小板膜糖蛋白 基因多态性 |
| 英文关键词: Aspirin resistance Platelet glycoprotein Gene polymorphism |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨青岛地区汉族人群阿司匹林抵抗与血小板膜糖蛋白GPⅢaPLA、Ⅰa807C/T 基因多态性之间的关系。方法：筛选
150 例动脉粥样硬化患者服用阿司匹林（100mg/d)至少14d 以上，根据血小板聚集功能测定将其分为阿司匹林抵抗(AR)组、阿司
匹林半抵抗(ASR)组，阿司匹林敏感(AS)组。用PCR-RFLP 法确定各组GPⅢaPLA、GPⅠa 807C/T 基因型。结果：仅于ASR 组检出
1 例PLA1/A2 基因型，其余均为PLA1/A1 基因型，未发现PLA2/A2 基因型，差异无统计学意义(P>0.005)；GPⅠa807C/T 基因位点
AR 组、ASR 组的T 等位基因频率均显著高于AS 组,有统计学意义(P<0.005)。结论：GPⅢaPLA2 基因可能不是阿司匹林抵抗的遗
传危险因素。而GPⅠa 807C/T 基因位点的T 等位基因与阿司匹林抵抗的发生相关联，可能是阿司匹林抵抗遗传易感因素。 |
| 英文摘要: |
| Objective: To investigate whether two Gene Polymorphisms of Platelet Glycoprotein, GPⅢa PLA and GPⅠa807C/T,
contribute to aspirin resistance in Han population of Qingdao. Methods: 150 patients with artherosclerosis on aspirin(100mg/d) for at least
14 days were enrolled. According to the Platelet agglutination test, they were divided to three groups: aspirin resistant(AR) group, aspirin
semiresponder (ASR) group and aspirin sensitive (AS) group, Genotyping of the two polymorphisms was performed using a polymerase
chain reaction-based restriction fragment-length polymorphism analysis. Results: Only one patient carried the PLA1/A2 allele. The others
possessed PLA1/A1 allele. None PLA2/A2 observed. No relation was found between resistance status and PLA genotype. For the 807C/T
genotype, the frequency of T allele in AR group and ASR group were higher than that in AS group. The difference was statistically Significant(
P<0.005). Conclusion: The present results suggest that the PLA polymorphism of glycoprotein Ⅲa is not a risk factor for AR. But
the 807T allele of the GPⅠa gene show higher relationship with aspirin resistance. It may be a genetic factor for susceptibility to AR. |
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