| 蒋春英高卫英张春雨刘远英李亚杰.特发性血小板减少性紫癜与巨细胞病毒、EB 病毒感染相关性[J].,2011,11(12):2292-2294 |
| 特发性血小板减少性紫癜与巨细胞病毒、EB 病毒感染相关性 |
| Correlation of Idiopathic Thrombocytopenic Purpura and Cytomegalovirus,EB Virus Infection |
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| DOI： |
| 中文关键词: 血小板减少性紫癜；特发性 巨细胞病毒；EB 病毒；ELISA |
| 英文关键词: Thrombocytopenic purpura Idiopathic Cytomegalovirus EB virus ELISA |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨小儿特发性血小板减少性紫癜（ITP）与巨细胞病毒、EB 病毒感染的关系。方法：实验组：48 例确诊断为ITP 患
儿，对照组：44 例同期呼吸道感染患儿，应用酶联免疫吸附法（ELISA） 对两组小儿外周血进行巨细胞病毒IgM 抗体
（HCMV-IgM）、EB 病毒感染IgM 抗体(EB-IgM)检测。结果：48 例ITP 患儿中HCMV-IgM 抗体阳性者20 例，阳性率为41.67%，明
显高于对照组，两组之间差异有显著性（P<0.01）；EBV-IgM 抗体阳性者14 例，阳性率为29.17%，明显高于正常对照组，两组之间
差异有显著性（P<0.05）。结论：1、巨细胞病毒感染是引起特发性血小板减少性紫癜的重要原因之一，且通过临床观察巨细胞病毒
感染引起的ITP 患儿病情重，病程长，治疗时间长，转为慢性ITP 的可能性大；2、EB 病毒感染可能是引起特发性血小板减少性紫
癜的原因之一，并且EB 病毒感染引起的特发性血小板减少性紫癜病情也偏重。 |
| 英文摘要: |
| Objective: To investigate children with idiopathic thrombocytopenic purpura (ITP) and CMV, EB virus infection.
Methods: Experimental group: 48 patients diagnosed with ITP in children is indeed the control group: 44 cases of children with
respiratory tract infection over the same period, enzyme-linked immunosorbent assay (ELISA) in peripheral blood of two groups of
children with IgM antibodies to cytomegalovirus (HCMV-IgM ), EB virus IgM antibody (EB-IgM) detection. Results: 48 cases of ITP
children with positive HCMV-IgM antibodies in 20 cases, the positive rate was 41.67%, significantly higher, the difference between the
two groups was significant (P <0.01); EBV-IgM antibodies in 14 cases, the positive rate was 29.17%, significantly higher than the control
group, the difference between the two groups was significant (P <0.05). Conclusion: 1, CMV infection is the cause of idiopathic
thrombocytopenic purpura is one of the important reasons, and through clinical observation of cytomegalovirus infection in ITP patients
with severe illness, longer duration, treatment for a long time to chronic ITP the possibility of large; 2, EB virus infection may be caused
by idiopathic thrombocytopenic purpura one of the reasons, and EB virus infection with idiopathic thrombocytopenic purpura is also
biased towards the disease. |
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