| 徐浩梁雪松△ 范文翰万谟.阿德福韦酯联合拉米夫定治疗乙型肝炎DNA 阳性肝硬化疗效观察[J].,2011,11(12):2276-2278 |
| 阿德福韦酯联合拉米夫定治疗乙型肝炎DNA 阳性肝硬化疗效观察 |
| Efficacy of Adefovir Dipivoxil and Lamivudine on Treatment of Hepatitis BRelated Cirrhosis with DNA Positive |
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| DOI： |
| 中文关键词: 乙型肝炎 肝硬化 阿德福韦酯 拉米夫定 |
| 英文关键词: Hepatitis B Cirrhosis Adefovir dipivoxil Lamivudine |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨阿德福韦酯联合拉米夫定治疗HBV DNA 阳性乙型肝炎肝硬化的疗效。方法：46 例HBV DNA 阳性乙肝肝硬化
患者随机分为对照组及观察组。在保肝等对症治疗基础上，观察组22 例患者联用阿德福韦酯与拉米夫定，对照组24 例患者予阿
德福韦酯，总疗程均为48 周。结果：在治疗12 周后，观察组与对照组HBV DNA 转阴率分别为54.5%、20.8%(P<0.05)，ALT 复常
率分别为63.6%、33.3% (P<0.05)。治疗24 周、48 周后上述指标无统计学差异。两组患者未见明显药物不良反应。结论：阿德福韦
酯联合拉米夫定治疗HBV DNA 阳性乙型肝炎肝硬化起效快，降低病毒载量疗效佳，安全性好。 |
| 英文摘要: |
| Objective: To investigate efficacy of adefovir dipivoxil and lamivudine on treatment of hepatitis B related cirrhosis
with DNA positive. Methods: 46 patients with liver cirrhosis and HBV DNA positive were randomly divided into the control group and
observation group. Based on the symptomatic treatment, the observation group (22 patients) were treated with adefovir dipivoxil
combined with lamivudine, and the control group (24 patients) were treated with adefovir dipivoxil. The total course of treatment was 48
weeks. Results: After 12 weeks of treatment, HBV DNA negative conversion rate of the observation and control group were 54.5% and
20.8%, respectively (P<0.05). ALT normalization rate of the observation and control group were were 63.6% and 33.3%, respectively
(P<0.05). After 24 weeks and 48 weeks of treatment, the above indexes showed no significant difference between the two groups. No
significant adverse drug reactions were found in the two groups. Conclusion:On treatment of hepatitis B related cirrhosis with DNA
positive, adefovir dipivoxil combined with lamivudine shows rapid onset, good effect in reducing viral load and good security. |
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