| 刘建华1 尚桂莲2 董明国1 李小好2 叶青跃1.急性冠状动脉综合症患者血浆溶血磷脂酸及基质金属蛋白酶-9
水平的检测及意义[J].,2011,11(10):1956-1958 |
| 急性冠状动脉综合症患者血浆溶血磷脂酸及基质金属蛋白酶-9
水平的检测及意义 |
| Detection and Significance of Lysophosphatidic Acid and MatrixMetalloproteinase-9 Levels in Patients with Acute Coronary Syndrome |
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| DOI： |
| 中文关键词: 急性冠状动脉综合症 溶血磷脂酸 基质金属蛋白酶-9 |
| 英文关键词: Acute coronary syndrome 1ysophosphatidic acid Matrix metalloproteinase-9 |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨急性冠状动脉综合症(acute coronary syndromes,ACS)患者血浆溶血磷脂酸(1ysophosphatidic acid，LPA)及基质金
属蛋白酶-9(matrix metalloproteinase-9,MMP-9)水平的变化，探讨其在ACS 中可能的临床意义。方法：入选100 例ACS 患者,根据
病情将其分为急性心肌梗死(AMI)组50 例, 不稳定型心绞痛（UAP）组50 例，并入选40 例健康者作为对照组，分别用无机磷定量
法和酶联免疫吸附测定法测定血浆LPA、MMP-9 水平。结果：AMI 组血浆LPA、MMP-9 水平显著高于UAP 组（LPA：3.29±
0.42vs2.67±0.37；MMP-9：481.7±86.5 vs 237.85±65.34，P<0.01） 并且两组均显著高于对照组(LPA:1.82±0.31; MMP-9:87.42±23.85
P<0.01); LPA 与MMP-9 水平呈正相关(r=0.224，P<0.05)。结论：LPA 与MMP-9 可能是提示不稳定斑块的形成、破裂，进而导致急
性冠状动脉综合征的危险信号。 |
| 英文摘要: |
| Objective: To investigate the level of plasma lysophosphatidic acid(LPA) and matrix metalloproteinase-9(MMP-9) in
patients with acute coronary syndromes(ACS) and to explore the potential clinical significance. Method: A total of 100 patients with ACS
were divided into two groups:group AMI(AMI) 50 and group unstable angina (UAP) 50,and 40 healthy persons served as control. Plasma
LPA and MMP-9 were determined by inorganic phosphours quantitative method and enzyme-linked immunosorbent assay. Result: LPA
and MMP-9 levels were significantly higher in AMI than in UAP（LPA：3.29±0.42vs2.67±0.37；MMP-9：481.7±86.5 vs 237.85±65.34，P<0.
01）,and in both group were higher than in control group (LPA:1.82 ±0.31; MMP-9:87.42 ±23.85 P<0.01); LPA level was positive
correlated with MMP-9 (r=0.224，P<0.05). Conclusion: LPA and MMP-9 may serve as a potential risk signal to hint the formation and
rupture of unstable atherosclerotic plaque of ACS. |
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