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目的：探讨负载金属离子的5A 沸石的体外抗菌作用。方法：选用金黄色葡萄球菌、铜绿假单孢菌、白色念珠菌，利用倍比稀释法对5A 沸石组、磺胺嘧啶银组及载不同浓度Ag+、Zn2+ 5A 沸石共15 组进行了体外抗菌试验研究，确定最佳抗菌效果离子负载方案。结果：三种细菌的MIC，双金属离子负载在抗菌上具有协同载Ag+5A 沸石分别达到了125μg/ml~ 500μg/ml、31.25μg/ml~ 500μg/ml、250μg/ml~ 500μg/ml；附载Zn2+5A 沸石分别达到了12.5mg/ml~25mg/ml、6.25mg/ml~ 50mg/ml、25mg/ml；负载双离子5A 沸石分别为250μg/ml~500μg/ml、62.5μg/ml~ 500μg/ml、500μg/ml。结论：5A 沸石负载金属离子后均具有抗菌作用，且抗菌作用与附载金属离子的量正相关；负载相同质量Ag+ 的5A 沸石较附载Zn2+ 者具有更强的抗菌作用；双金属离子负载在抗菌上具有协同作用；2%Ag++8%Zn2+ 与2%Ag++10%Zn2+ 及4%载银组与阳性对照组无显著性差异。

英文摘要:

Objective: To explore the 5A zeolite load metal ions in vitro antibacterial action. Methods: Select staphylococcus aureus, the pseudomonas aeruginosa, candida albicans, use times than dilution method to study the vitro antibacterial experiment on 5A zeolite group, sulfonamides silver group, and altogether 15 groups which bases loaded with different concentrations Ag+, Zn2+, 5A zeolite. In the end we determine the optimal antibacterial effect ion load scheme. Results: These three kinds of bacteria in the MIC, loaded with Ag +, 5A zeolite respectively reached 125mg/ml ~ 500mg/ml, 31.25 mg/ml ~ 500mg/ml, 250mg/ml ~ 500mg/ml and loaded with Zn2+ 5A zeolite respectively reached 12.5 mg/ml ~ 25mg/ml, 6.25 mg/ml ~ 50mg/ml, 25mg/ml, loaded with double ion 5A zeolite respectively reached 250mg/ml ~500mg/ml, 62.5mg/ml~500mg/ml, 500mg/ml. Conclusion: 5A zeolite loaded with metal ions all have the antibacterial effect, and the amount that the antibacterial action is positive correlation with the metal ions'amount.Loaded with the same quality of 5A zeolite Ag+ has a stronger antibacterial action than those loaded with Zn2+. Dual metal ions loaded material has a collaborative effect in antibacterial property. Meanwhile, 2% Ag+ +8%Zn2+,2% Ag+ +10%Zn2+ with 4% silver group have no significant differences from the positive control group.

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