| 姜涌斌彭颖关国跃李金鹆金开山.2 型糖尿病患者幽门螺杆菌感染与超敏c 反应蛋白、血脂情况的关系[J].,2011,11(8):1549-1552 |
| 2 型糖尿病患者幽门螺杆菌感染与超敏c 反应蛋白、血脂情况的关系 |
| Relationship between hs-C-reactive protein and blood fat and helicobacterpylori infection in type 2 diabetes |
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| DOI： |
| 中文关键词: 2 型糖尿病幽门螺杆菌超敏c 反应蛋白血脂 |
| 英文关键词: Type 2 Diabetes, Helicobacter Pylori, high-sensitivity C-reactive protein,Blood Lip |
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| 中文摘要: |
| 目的：探讨2 型糖尿病（T2DM）患者幽门螺杆菌（HP）感染与超敏c 反应蛋白（hs-CRP）、血脂水平的关系。方法：以2009 年1
月1 日至2009 年12 月31 日在我院体检的683 例2 型糖尿病患者为研究对象，根据HP 感染情况分成HP 阳性组（n=306）和HP
阴性组（n=377），采用单因素和多因素Logistic 回归分析方法，分析HP 感染与hs-CRP、血脂水平的关系。结果：（1）HP 阳性组的
hs-CRP 水平高于HP 阴性组（1.14mg/L vs 0.96mg/L），差异有统计学意义（P <0.05）。（2）HP 阳性组的血脂异常率（59.8% vs 50.7%）
和hs-CRP 异常率（20.9% vs 14.3%）均高于HP 阴性组，差异均有统计学意义（均P <0.05）。（3）单因素Logistic 回归分析显示，血
脂异常和hs-CRP 异常对HP 阳性的OR 值及分别为1.449 和1.582，均有统计学意义（均P <0.05），多因素Logistic 回归分析显
示，hs-CRP 异常对HP 阳性的OR 值为1.509，有统计学意义（P <0.05）。结论：2 型糖尿病患者，HP 感染可能通过增高hs-CRP 水
平，影响脂质代谢，触发一系列生物、生物化学级联反应，可使患者并发心血管病变的风险性增高。 |
| 英文摘要: |
| Objective : To explore the relationship between high-sensitivity C-reactive protein (hs-CRP) and Blood Fat and
Helicobacter pylori infestation Among Type 2 Diabetes. Methods: A tatol of 683 Type 2 Diabetes who were doing health examination in
our sanatorium were included in the present study from January 1st,2009 to December 31st,2009.These individuals were separated into
two groups according to the helicobacter pylori(HP) infestation state.One is the HP Positive group (n=306), the other is the HP Negative
group (n=377). The associations between hs-CRP and Blood Fat and Helicobacter pylori infestation were analyzed by using single and
multiple logistic models. Results: (1)The hs-CRP levels in the HP Positive group were higher than the HP Negative group(1.14mg/L vs
0.96mg/L), the difference has statistical significance,P<0.05.(2)The dyslipdemia rates (59.8% vs 50.7%)and hs-CRP abnormity rates
(20.9% vs 14.3%) in the HP Positive group were all higher than the HP Negative group,all P<0.05. (3)Single Logistic regression analysis
manifest that the odds ratio of dyslipdemia and abnomal hs-CRP was 1.449 and 1.582,separately, all P<0.05. Multivariate-adjusted odds
ratio of hs-CRP was 1.509, P<0.05.Conclusion: The HP infection may affect the lipid metabolism through the hs-CRP elevation in Type
2 Diabetes，these will trigger a series of biology or biochemistry cascade reactions which will cause a higher complic risk of vascylopathy
in these patients. |
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