| 黄鹏1 刘希光1△ 宋浩1 宋婷婷2 王海超1.非小细胞肺癌EGFR 表达与18F-FDG-PET SUVmax 值
的相关性研究[J].,2011,11(8):1479-1483 |
| 非小细胞肺癌EGFR 表达与18F-FDG-PET SUVmax 值
的相关性研究 |
| Correlation Between the Expression of EGFR and 18F-FDG-PETSUVmax in Non-small Cell Lung Cancer |
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| DOI： |
| 中文关键词: 表皮生长因子受体 最大标准摄取值 非小细胞肺癌 免疫组化 |
| 英文关键词: Epidermal growth factor receptor (EGFR) Standardized uptake value (SUV) Non-small cell lung cancer (NSCLC) Immunohistochemistry |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨非小细胞肺癌组织中EGFR 蛋白在的表达与PET-CT 检测的SUVmax 的相关性。方法：临床收集30 例非小细胞
肺癌患者，每一病例首先行PET-CT 检查，然后行CT 导引下活检穿刺，同一病灶取2 个穿刺部位,分别为肿瘤组织内SUVmax 值
2.5-5 区域及SUVmax>5 区域，采用免疫组化方法检测检测30 例非小细胞肺癌肿瘤内部不同部位EGFR 表达。结果: EGFR 蛋白
表达、SUVmax 值在不同年龄、性别、病理类型中表达的差异无统计学意义(P 均>0.05)。EGFR 蛋白表达、SUVmax 值在不同的肿
瘤直径、临床分期组表达差异有统计学意义(P 均<0.05)。NSCLC 肿块SUVmax 值与组织EGFR 表达呈显著正相关(P <0.05)。结
论：NSCLC 组织SUV 值与组织EGFR 表达有显著相关性，可以为非小细胞肺癌的放疗提供指导。 |
| 英文摘要: |
| Objective: To investigate the relationship between the expression of EGFR (epidermal growth factor receptor) and
SUVmax (standard uptake value maximum) in non-small cell lung cancer （NSCLC）. Methods: 30 patients with non-small cell lung
cancer and undergone PET-CT scan were registered. The two areas with different SUV max (2.5-5 vs.5 or more) of patients' tumor tissue
were taken by needle puncture biopsy under the CT guidance.Expression of EGFR of the two areas were detected and analyzed by
immunohistochemical staining. Results:There was no statistical difference for the expression of EGFR and SUVmax in age, gender,
Pathology and differentiation (P>0.05). The expression of EGFR and SUVmax has respectively Significant difference in tumor size and
clinical Stage (P<0.05). The SUVmax was correlated positively with the expression of EGFR (r = 0.836, P<0.05).Conclusions: The
SUVmax is correlated positively with EGFR expression in NSCLC, which can provide the guidance for radiotherapy. |
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