| 张延霞张桂青.难治性抑郁症的发病机制研究现状[J].,2011,11(6):1194-1196 |
| 难治性抑郁症的发病机制研究现状 |
| On Pathogenesis of Treatment-Resistant Depression |
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| DOI： |
| 中文关键词: 难治性抑郁症 发病机理 |
| 英文关键词: TRD etiology |
| 基金项目: |
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| 中文摘要: |
| 抑郁症是一种高患病率、高致残率及高自杀率的严重精神疾患。在过去10 年中,抗抑郁药物研究取得了突飞猛进的进展。然
而,在临床上仍约有20％的抑郁症患者最终成为难治性抑郁症病例。难治性抑郁症是一种情感障碍，目前尚无较好的治疗策略。
现对有关难治性抑郁症的病因学现状进行文献回顾与总结，了解难治性抑郁症的发病机制，便于从临床治疗角度早期识别该类
患者，尽可能及早地给予积极的抗抑郁治疗，以提高临床缓解率。 |
| 英文摘要: |
| Depression is a highly prevalent and disabling condition associated with significant morbidity and mortality. Although
the therapeutic armamentarium available for clinicians treating depression patients has expanded substantially over the last decade, up to
20 % of depression patients eventually present with treatment - resistant depression (TRD). However, the optimal strategy for treating
TRD has yet to be identified. TRD is a kind of affective disorders.We have reviewed and summarized the literatures about current etiology
of TRD to understand the etiology of TRD. So we could recognize this kind of patients earlier from the view of clinical treatment, give
the proactive anti-depression treatments as soon as possible and improve clinical remission rate. |
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