| 黄晓梅1 陈协群1△ 高广勋1 余芳1 肖春2.滤泡辅助性T 细胞在特发性血小板减少性紫癜患者的变化及其意义*[J].,2011,11(5):827-829 |
| 滤泡辅助性T 细胞在特发性血小板减少性紫癜患者的变化及其意义* |
| T Follicular Helper Cells in Peripheral Blood of Patients with ImmuneThrombocytopenic Purpura* |
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| DOI： |
| 中文关键词: 滤泡辅助性T 细胞 CXCR5 CD4 IL-21 特发性血小板减少性紫癜 |
| 英文关键词: Tfh CXCR5 CD4 IL-21 ITP |
| 基金项目:国家自然科学基金（C140202） |
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| 中文摘要: |
| 目的：研究滤泡辅助性T 细胞（T follicular helper cells，Tfh）在免疫性血小板减少性紫癜（immune thrombocytopenic purpura ，
ITP）患者的表达并探讨其临床意义。方法：用流式细胞术检测20 例健康人、25 例ITP 患者外周血CXCR5+CD4+T 细胞占CD4+ T
细胞的比例。结果：与健康对照组相比，ITP 患者外周血CXCR5+CD4+ T 细胞占CD4+ T 细胞的比例显著增高（P<0.05）。结论：
Tfh 在ITP 患者外周血比例增高，为Tfh 能否为ITP 的免疫调节和干预提出新的方向提供了证据。 |
| 英文摘要: |
| Objective: To investigate the expression of the T follicular helper cells (Tfh) in in peripheral blood of patients with
immune thrombocytopenic purpura (ITP). Methods: 25 patients with ITP and 20 healthy adults without immunologic diseases or
infectious disorders were chosen in this study.Peripheral blood was stained with anti- CD4-FITC and anti-CXCR5-PerCP. For cell surface
staining, both Abs were added and cells were stained for 30 minutes. Stained cells were examined by flow cytometric. Results: The ratio
of CXCR5+CD4+ T cells in ITP patients is significantly higher than that in the control group [(13.8±0.41% VS 9.6±0.30) P<0.05].
Conclusion: The ratio of Tfh increased in ITP patients. Tfh might play a role in evaluation and treatment of ITP. |
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