| 金跃1 张建明1 陈建平1 潘玉琴2 何帮顺2 王书奎2△.哮喘患者外周血Treg和Th1/Th2的变化及其与哮喘病情的关系[J].,2011,11(2):326-328 |
| 哮喘患者外周血Treg和Th1/Th2的变化及其与哮喘病情的关系 |
| The changes of regulatory T cells and T helper cell in peripheral bloodand their significance in patients with asthma |
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| DOI： |
| 中文关键词: 哮喘 调节性T细胞 辅助性T细胞 流式细胞术 |
| 英文关键词: Asthma Regulatory T cells T helper cell Flow cytometry |
| 基金项目:南京医科大学科技发展基金面上项目( 09NMUM070 ) |
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| 中文摘要: |
| 目的：探讨哮喘患者外周血调节性T细胞(Treg)以及辅助性T细胞（Th1/Th2）的比例的变化，探讨其在哮喘的临床治疗中的
作用。方法：80例哮喘患者(哮喘组)按临床表现分为急性发作期组(54例)和缓解期组(26例)，同时选择50例健康体检者。应用流
式细胞仪检测上述各组外周血CD4+CD25+Foxp3+ Treg、CD4+IFN-γ+ Th1 和CD4+IL-4+Th2 细胞水平，并进行统计学分析。结果：哮
喘组CD4+CD25+Foxp3+ Treg水平亦明显低于正常对照组( P<0.05。其中急性发作期组Treg水平明显低于缓解期组和正常对照组
(P <0.05)。而哮喘组Th1/Th2 比值显著低于对照组( P <0.05)，且在哮喘急性发作组中Th1/Th2 比值显著低于缓解期组和正常对照
组(P <0.05)。结论：提示Treg和Th 在哮喘的发生和发展中起着重要的作用。 |
| 英文摘要: |
| Objective: To investigate the changes of CD4+CD25+Foxp3+ regulatory T cells ( Treg) and T helper cell (Th1/Th2) in
peripheral blood and their significance in the severity of patients with asthma. Methods: Eighty patients with asthma (asthma group) were
divided into acute attack stage group (54 cases) and remission stage group (26 cases) according to their clinical features, Meanwhile, fifty
health volunteers were enrolled as control group. The levels of CD4+CD25+Foxp3+ Treg, CD4+IFN-γ+ Th1and CD4+IL-4+ Th2 in peripheral
blood of all children were tested by flow cytometer( FCM), and analyzed statistically. Results: The levels of CD4+CD25+Foxp3+ Treg
of patients with asthma were lower than those in the control group (P<0.05). The Treg levels in acute patients group were lower than
those in remission group or in the control group (P< 0.05). The ratio of Th1/Th2 of patients with asthma were lower than those in the control
group (P<0.05), and The Th1/Th2 ratio in acute attack group were lower than those in remission group or in the control group (P<0.
05). Conclusion: Tregand Th immunity plays an important role in the pathogenesis of asthma.. |
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