| 刘中华陈建英田政湘李丽珍.慢性肾小球肾炎患者治疗前后血清CRP和VEGF浓度变化及临床意义[J].,2011,11(2):323-325 |
| 慢性肾小球肾炎患者治疗前后血清CRP和VEGF浓度变化及临床意义 |
| Clinical significance of detection of serum CRP and VEGF levels beforeand after treatment in patients with chronic glomerular nephritis |
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| DOI： |
| 中文关键词: 慢性肾小球肾炎 C反应蛋白 血管内皮生长因子 尿白蛋白 |
| 英文关键词: Chronic glomerular nephritis CRP VEGF Alb |
| 基金项目: |
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| 中文摘要: |
| 目的：研究慢性肾小球肾炎（CNG）中血清C反应蛋白（CRP）和血管内皮生长因子（VEGF）的浓度变化及其临床意义。方法：
采用ELISA法测定35例正常对照组与41 例慢性肾小球肾炎患者治疗前后血清IL-6 和VEGF的浓度，同时放射免疫分析法测
定血清TNF-α浓度，免疫比浊法测定血清CRP与尿Alb 浓度。结果：①治疗前后CNG患者血清中IL-6、TNF-α和CRP较正常
对照组均显著升高(P<0.05 或P<0.01)，但治疗后IL-6、TNF-α 和CRP水平显著低于治疗前（P<0.01)，且血清CRP与IL-6 和
TNF-α 呈正相关（P<0.01)。②治疗后，CNG患者血清VEGF水平与尿Alb 含量较治疗前明显降低(P<0.05或P<0.01)，仍显著高于
正常对照组(P<0.05或P<0.01)，且血清VEGF与尿Alb 水平呈正相关(P<0.01)。结论：CRP、IL-6和TNF-α参与了CNG患者慢性
炎症反应，VEGF则与蛋白尿的产生密切相关，治疗前后血清CRP和VEGF检测对于慢性肾小球肾炎的病情了解及临床疗效评
估均具有重要的临床价值。 |
| 英文摘要: |
| Objective: To study the level changes of serum C reactive protein (CRP) and vascular endothelial growth factor
(VEGF), and the clinical significance of detection of CRP and VEGF. Methods: Serum IL-6 and VEGF were determined by ELISA assay
in 41 patients with CNG and 35 normal people. The radio immunoassay was applied to detect serum TNF-α, and immunoturbidimetry to
detect serum CRP and urine Alb. Results: ① Serum IL-6, TNF-α and CRP in patients with CNG were higher than control group (P<0.
01), and Serum IL-6, TNF-α and CRP in patients after treatment were significantly lower than before treatment (P<0.01). There were
positive correlation between serum IL-6, TNF-α and CRP levels (P<0.01). ②After treatment, the serum CRP and urine Alb significantly
decreased (P<0.01 or P<0.05), but still higher than control group (P<0.01). The serum VEGF levels were positively correlated with urine
Alb (P<0.01). Conclusion: IL-6, TNF-α, CRP may be involved in chronic inflammatory process in CNG, and VEGF has close relationship
with proteinuria. Detection of serum CRP and VEGF before and after treatment plays important role in understanding the pathogenetic
condition and observing efficacy of patients with CNG. |
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