| Objective: To study the significance of Hcy, ET-1, hs-CRP, TXA2, parameters of coagulation and fibrinolysis in
patients with acute cerebral infarction (ACI) before and after treatment. Methods: ELISA, chromogenic substrate assay, Clauss assay,
radioimmune and immune turbidimetric method were used to determine levels of Hcy, ET-1, hs-CRP, TXA2, parameters of coagulation
and fibrinolysis in 68 case with ACI before and after treatment, as well as in 30 control normal cases. Results: ① Before treatment, the
levels of plasma Hcy, ET-1 and serum hs-CRP, TXA2 significantly increased in patients with ACI, higher than those in control group
(P<0.01), which decreased after treatment, especially plasma Hcy and ET-1 (P>0.05). ② The levels of plasma ET-1 and serum hs-CRP,
TXA2 gradually increased from minor to severe grade (P<0.01 or 0.05), while the level of plasma Hcy in modest and severe grade was
significantly higher than minor grade (P<0.01). ③ After treatment, the levels of plasma vWF、GMP-140, Fg and F1+2 were significantly
lower than those before treatment, but plasma PS, PC and AT higher than before treatment (P<0.01), and there was no difference in levels
of PS, PA between ACI patients and control group (P>0.05). ④ The concentration of plasma tPA was significantly lower than control
group, while plasma PAI-1 higher than control before treatment (P<0.01 or 0.05). After treatment, tPA increased and PAI-1 decreased,
but the level of PAI-1 remained significantly different from control (P<0.05). Conclusion: Levels of Hcy, ET-1, hs-CRP, TXA2, parameters
of coagulation and fibrinolysis could guide drug therapy, evaluate disease severity and its prognosis in patients with ACI. |
