| 于殿君孙晓文△ 施云峰刘世博.前列腺癌雄激素受体和PI3K/Akt 信号通路相互作用研究进展[J].,2011,11(1):180-183 |
| 前列腺癌雄激素受体和PI3K/Akt 信号通路相互作用研究进展 |
| Research Progress in Interaction of Androgen Receptor and PI3K/AktPathway in Prostate Cancer |
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| DOI： |
| 中文关键词: 雄激素受体 前列腺癌 Akt |
| 英文关键词: Prostate cancer Androgen receptor PI3K Akt |
| 基金项目:国家自然科学基金（30600618） |
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| 中文摘要: |
| 前列腺癌的发生、进展依赖于雄激素，因此去势手术成为治疗晚期前列腺癌的标准疗法。但是去势后大多前列腺癌最终将
转化为雄激素非依赖性前列腺癌，甚至进展为激素难治性前列腺癌，使得肿瘤的进展不受低水平雄激素的影响。即使如此，大多
数激素非依赖性前列腺癌，依然阳性表达雄激素受体。因而雄激素受体在前列腺癌发生发展中起着重要作用。而PI3K/Akt 信号通
路能够通过维持细胞生存、抑制细胞凋亡、促进细胞代谢及血管生成等促进前列腺癌进展。本综述旨在总结前人研究，阐述雄激
素受体和PI3K/Akt 信号通路之间相互作用关系。研究表明Akt 信号通路能够正性或者负性调控AR 蛋白表达、蛋白的稳定性及
其转录活性，从而维持细胞的生存、代谢。而AR 即可以通过基因转录途径抑制Akt 活化又能通过非转录基因途径激活Akt 及其
下游蛋白。因此，AR 和Akt 信号通路相互协同促进前列腺癌的发生及其向雄激素非依赖性前列腺癌进展。 |
| 英文摘要: |
| The growth of prostate cancer dependent on androgen, however most of prostate cancer may result in progression to
androgen independence after ADT （androgen deprived therapy）. Even so androgen receptors express in majority of androgen independent
prostate cancer. Therefore androgen receptor is important in the progression of prostate cancer. The Akt signaling pathway promotes
the aggressive of prostate cancer, by the maintenance of cell survival, cell metabolism and angiogenesis, inhibiting apoptosis. In this
review, we described interaction between androgen receptor and the Akt signaling pathways by summarizing previous research. Akt signaling
pathway can be positive or negative regulation of AR protein expression, and its stability and transcriptional activity, thereby
maintaining cell survival, metabolism. In addition, androgens regulate the Akt pathway by both genomic and non-genomic effects. The
synergy between Akt and AR signaling that is sufficient to initiate and progress native adult murine prostatic epithelium to frank
carcino- ma and override the effect of androgen ablation. |
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