| 刘健1 丁永忠2 李强2 任军2 张海林2.GSTP1、E-cadherin 在垂体腺瘤中的表达及临床意义[J].,2011,11(1):118-123 |
| GSTP1、E-cadherin 在垂体腺瘤中的表达及临床意义 |
| Expressions of GSTP1 and E-cadherin in Pituitary Adenomas and TheirClinical Features |
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| DOI： |
| 中文关键词: 垂体腺瘤 谷胱甘肽S- 转移酶P1 上皮钙粘蛋白 免疫组织化学 |
| 英文关键词: Pituitary adenoma Glutathione S-transferases P1 E-cadherin lmmuuohistoehemistry |
| 基金项目:兰州大学医学科研基金项目（LZUYX200735） |
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| 中文摘要: |
| 目的：研究谷胱甘肽S- 转移酶P1（GSTP1）、上皮钙粘蛋白(E-cadherin)在垂体腺瘤中的表达及临床意义。方法：应用免疫组
化SP 染色法检测30 例侵袭性垂体腺瘤与30 例非侵袭性垂体腺瘤中GSTP1、E-cadherin 的表达。结果：GSTP1 在侵袭性垂体腺
瘤中的表达较非侵袭性垂体腺瘤显著降低（P<0.05）；E-cadherin 在侵袭性垂体腺瘤中的表达较非侵袭性垂体腺瘤显著降低（P<0.
05）；GSTP1、E-cadherin 在垂体腺瘤中的表达呈正相关(r=0.82, P<0.05)。结论：GSTP1、E-cadherin 在垂体腺瘤中的表达与肿瘤侵袭
程度显著相关，两者联合检测有助于判断垂体腺瘤侵袭性及预后。 |
| 英文摘要: |
| Objective: To investigate the expressions of Glutathione S-transferases P1 (GSTP1) and E-cadherin in pituitary adenomas
and analyze their clinical significance. Methods: The SP immunohistochemical method was used to detect the expressions of GSTP1
and E-cadherin in 30 invasive pituitary adenomas and 30 noninvasive pituitary adenomas. Results: Expression of GSTP1 was significantly
lower in invasive pituitary adenomas than in noninvasive pituitary adenomas (P<0.05); expression of E-cadherin protein was significantly
lower in invasive pituitary adenomas than in noninvasive pituitary adenomas(P<0.05); expression of GSTP1 has positive correlation with
the expression of E-cadherin in pituitary adenomas (r=0.82, P<0.05). Conclusions: The expressions of GSTP1 and E-cadherin are closely
correlated with aggressive pituitary adenoma behavior, which are helpful for the evaluation of tumor invasion and prognosis. |
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