| 郭晓东李捍卫张敏熊璐梁丽马雪梅赵景民△.MMP-2、MMP-9 及P53 的表达在肝移植后肿瘤复发与转移预测中
的价值研究[J].,2011,11(1):90-93 |
| MMP-2、MMP-9 及P53 的表达在肝移植后肿瘤复发与转移预测中
的价值研究 |
| Value of expression of MMP-2,MMP-9 and P53 in forecast of tumorrecurrence and metastasis after liver transplantation |
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| DOI： |
| 中文关键词: 肝肿瘤 肝移植 复发 转移 基质金属蛋白酶 P53 |
| 英文关键词: liver cancer liver transplantatioin recurrence metastasis MMP p53 |
| 基金项目:解放军第302 医院院内课题（2009007 号） |
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| 中文摘要: |
| 目的：探讨MMP-2、MMP-9 及P53 的表达在预测肝癌行肝移植后肿瘤复发与转移中的价值。方法：选择肝癌行全肝移植患
者85 例，应用免疫组化方法检测其切除的肝癌组织中MMP-2、MMP-9 及P53 的表达，并对患者进行移植术后随访，观察术后肝
癌复发与转移情况。分析MMP-2、MMP-9 及P53 的表达与移植后肝癌复发与转移之间的关系和意义。结果：肝癌组织中MMP-2、
MMP-9 及P53 阳性表达率均明显高于癌旁组织(P<0.01)。MMP-2 表达与肝癌肿瘤直径、TNM 分期、病理分级及门静脉癌栓显著
相关性(P<0.05), MMP-9 表达与肝癌肿瘤直径、TNM 分期、门静脉癌栓及肿瘤包膜显著相关性(P<0.05)，P53 表达与肝癌肿瘤直
径、门静脉癌栓及肿瘤包膜显著相关性(P<0.05)。MMP-2、MMP-9 在未复发和转移组中的表达明显低于复发和转移组(P<0.05)，而
P53 在两组间的表达差异无显著性(P＞0.05)。肝癌组织中MMP-2、MMP-9 高阳性表达均是预测肝癌患者肝移植后肿瘤复发和转
移的独立预见因子，而P53 未显示其具有预测意义。结论：MMP-2、MMP-9 及P53 在肝癌组织中呈高表达，MMP-2、MMP-9 的表
达水平可以有效预测肝癌患者肝移植后肿瘤复发和转移。 |
| 英文摘要: |
| Objective: To explore the value of the expression of MMP-2, MMP-9 and P53 in the tumor recurrence and metastasis
after liver transplantation. Methods: We chose 85 hepatic cancer patients with total liver transplantation, and detected the expression of
MMP-2, MMP-9 and P53 in the tissues of hepatic cancer by using immunohistochemistry. Meanwhile, we followed up these patients with
liver transplantation, and observed the tumor recurrence and metastasis after liver transplantation. The relation and significance of
MMP-2, MMP-9 and P53 in the tumor recurrence and metastasis after liver transplantation was analyzed. Results: Compared with adjacent
tissues, the rate of positive expression of MMP-2, MMP-9 and P53 was significantly increased. The expression of MMP-2 had obviously
correlation with tumor diameter, staging of TNM, pathological grade and portal vein tumor thrombus (P<0.05).The expression of
MMP-9 had obviously correlation with tumor diameter, staging of TNM, portal vein tumor thrombus and tumor capsule (P<0.05). The
expression of P53 had obviously correlation with tumor diameter, portal vein tumor thrombus and tumor capsule (P<0.05). Compared
with group of recurrence and metastasis, the expression of MMP-2 and -9 in the group of none recurrence and metastasis was significantly
lower(P<0.05), and there was no significant between two groups about the expression of P53(P＞0.05). The high positive expression of
MMP-2 and -9 in the tumor tissues were the independently predicted factors in the forecast of tumor recurrence and metastasis in the
hepatic cancer patients with liver transplantation, but not P53 gene. Conclusion: The expression of MMP-2, MMP-9 and P53 in the hepatic
cancer tissues was increased and had a valuable forecast for the tumor recurrence and metastasis in the hepatic cancer patients with liver
transplantation. |
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