| 吴长德1, 2 赵德明1 杨建民1 周向梅1.传染性海绵状脑病的诊断进展和存在的问题[J].,2006,6(7):57-59 |
| 传染性海绵状脑病的诊断进展和存在的问题 |
| Progress and problems in the diagnostics of transmissible spongiform encephalopathy |
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| DOI： |
| 中文关键词: 传染性海绵状脑病 诊断 进展 |
| 英文关键词: Transmissible spongiform encephalopathy diagnosis progress |
| 基金项目:国家自然科学基金资助项目( No. 30400325; 30571399) |
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| 中文摘要: |
| 传染性海绵状脑病是由朊病毒引起的人和多种哺乳动物以神经退行性变化为主要特征的一种慢性致死性传染病。引
起这类疾病的病原因子是一种编码宿主蛋白的PrPC 转变为异常的PrPSC 沉积在大脑, 导致传染性海绵状脑病的发生。本文从临
床症状识别、组织病理学诊断、致病性朊蛋白检测、生物学测定以及毒株鉴定等几个方面作一回顾和总结, 为揭示朊病毒疾病致
病机理和诊断研究提供借鉴。 |
| 英文摘要: |
| The transmissible spongiform encephalopathies ( TSEs) , are a group of chronic fatal neurodegenerative diseases in humans
and in a variety of mammalian animals. These prion diseases are associated with the deposition of PrPSc, a disease- specific isoform of the host
- encoded cellular prion protein ( PrPC) , which accumulates in the brain affected with most forms of TSE. This article reviews and summarizes
recent progress in the areas of the recognition of characteristic clinical signs, the diagnoses of histopathology, the detection of diseases- associated
prion protein and the characteristic in biology, distinguish the strain of TSE, and expected it can use for reference of prion pathogenesis and diagnostics. |
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